Impressive progress has been made over the last several years toward understanding how almost every aspect of the immune system contributes to the expression of systemic autoimmunity. In parallel, studies have shed light on the mechanisms that contribute to organ inflammation and damage. New approaches that address the complicated interaction between genetic variants, epigenetic processes, sex and the environment promise to enlighten the multitude of pathways that lead to what is clinically defined as systemic lupus erythematosus. It is expected that each patient owns a unique 'interactome', which will dictate specific treatment.

中文翻译：

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系统性红斑狼疮的自身免疫和器官损害。

在过去的几年中，在了解免疫系统几乎各个方面如何促进全身性自身免疫的表达方面取得了令人印象深刻的进步。同时，研究揭示了导致器官炎症和损伤的机制。解决遗传变异，表观遗传过程，性别与环境之间复杂相互作用的新方法有望启发多种途径，这些途径导致临床上定义为系统性红斑狼疮。期望每个患者拥有一个独特的“相互作用组”，这将决定具体的治疗方法。