Proteins containing heme groups perform a variety of important functions in living organisms. The heme groups are involved in catalyzing oxidation/reduction reactions, in electron transfer, and in binding small molecules, like oxygen or nitric oxide. Flavonoids, low molecular weight plant polyphenols, are ubiquitous components of human diet. They are also components of many plant extracts used in herbal medicine as well as of food supplements. Due to their relatively low reduction potential, flavonoids are prone to oxidation. This paper provides a review of redox reactions of various heme proteins, including catalase, some peroxidases, cytochrome P450, cytochrome c, myoglobin, and hemoglobin with flavonoids. Potential biological significance of these reactions is discussed, in particular when flavonoids are delivered to the body at pharmacological doses.

中文翻译：

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血红素蛋白与类黄酮的氧化还原反应。

含有血红素基团的蛋白质在活生物体中具有多种重要功能。血红素基团参与催化氧化/还原反应，电子转移以及结合小分子，例如氧或一氧化氮。类黄酮，低分子量植物多酚，是人类饮食中普遍存在的成分。它们还是草药中使用的许多植物提取物以及食品补充剂的成分。由于黄酮类化合物的还原电位较低，因此容易氧化。本文概述了各种血红素蛋白的氧化还原反应，包括过氧化氢酶，某些过氧化物酶，细胞色素P450，细胞色素c，肌红蛋白和血红蛋白与类黄酮的反应。讨论了这些反应的潜在生物学意义，