Research question

Does obesity affect endometrial gene expression in women with endometriosis, specifically women with stage I disease?

Design

Differential gene expression analysis was conducted on endometrium from women with and without endometriosis (n = 169). Women were diagnosed after surgical visualization and staged according to the revised American Society for Reproductive Medicine (stage I-IV). Women were grouped by body mass index (BMI) (kg/m²) as underweight, normal, pre-obese or obese. After accounting for menstrual cycle stage, endometrial gene expression was analysed by BMI (continuous and grouped) in women with endometriosis, and in non-endometriosis controls.

Results

No significant interaction effect was found between BMI and endometriosis status on endometrial gene expression. We have previously reported that obese women with endometriosis have a reduced incidence of stage I disease; however, stratifying our analysis into stage I endometriosis versus combined II, III and IV endometriosis failed to reveal any differentially expressed endometrial genes between normal, pre-obese and obese patients.

Conclusions

Despite obesity having deleterious effects on endometrial gene expression in other gynaecological pathologies, e.g. endometrial cancer and polycystic ovary syndrome, our results do not support an association between BMI and altered endometrial gene expression in women with or without endometriosis.

中文翻译：

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肥胖症不会改变子宫内膜异位症女性的子宫内膜基因表达。

研究问题

肥胖是否会影响子宫内膜异位症妇女（特别是患有I期疾病的妇女）的子宫内膜基因表达？

设计

对有和没有子宫内膜异位症的妇女的子宫内膜进行差异基因表达分析（n = 169）。妇女经过手术可视化后被诊断，并根据修订后的美国生殖医学学会（I-IV期）分期。根据体重指数（BMI）（kg / m ²）将妇女分为体重过轻，正常，肥胖前或肥胖。在考虑了月经周期阶段后，通过BMI（连续和分组）分析了子宫内膜异位症女性患者和非子宫内膜异位女性的子宫内膜基因表达。

结果

BMI和子宫内膜异位状态对子宫内膜基因表达没有发现显着的相互作用。先前我们曾报道过，患有子宫内膜异位症的肥胖女性的I期疾病发病率降低。然而，将我们的分析分为I期子宫内膜异位症与II，III和IV型子宫内膜异位症的比较，未能揭示正常，肥胖前期和肥胖患者之间子宫内膜基因的差异表达。

结论

尽管肥胖症对其他妇科病理学例如子宫内膜癌和多囊卵巢综合征的子宫内膜基因表达具有有害影响，但我们的结果并不支持在有或没有子宫内膜异位症的女性中BMI与子宫内膜基因表达改变之间的关联。