One-half million people joined the UK Biobank, described in the consent form as a “public good resource” with an overarching goal to support research to “promote health throughout society” (1). The study by Arthur et al. (2) in this issue of the Journal of the National Cancer Institute, which used this shared resource, is a positive step towards fulfilling the contract the UK Biobank made with participants to serve the public good. The investigators used available genetic and questionnaire data to examine whether behavioral factors may modify inherited genetic risk for breast cancer and found that a healthier lifestyle was associated with a lower risk of breast cancer, especially among those with the highest polygenic risk score. The analysis highlights the societal benefit of data sharing and lends support to further defining synergistic models to inform population guidance.

中文翻译：

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公益数据共享

一半的人加入了英国生物银行，在同意书中被称为“公共物品资源”，其首要目标是支持“促进全社会健康”的研究（1）。亚瑟等人的研究。（2）本期《美国国家癌症研究所杂志》使用此共享资源，是朝履行UK Biobank与参与者签订的为公益服务的合同迈出的积极一步。研究人员使用可用的遗传和问卷调查数据检查了行为因素是否可以改变遗传的乳腺癌遗传风险，并发现更健康的生活方式与较低的乳腺癌风险相关，尤其是在多基因风险评分最高的人群中。该分析突出了数据共享的社会效益，并为进一步定义协同模型以指导人群提供了支持。