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Links between metabolic syndrome and the microbiome
Evolution, Medicine, and Public Health ( IF 5.143 ) Pub Date : 2020-02-19 , DOI: 10.1093/emph/eoaa007
Theresa E Gildner 1
Affiliation  

Metabolic syndrome (MetS) is a cluster of harmful conditions which occur together, such as insulin resistance, abdominal obesity, and hypertension. The global prevalence of MetS is growing rapidly, with some estimates suggesting over one billion people worldwide experience increased morality and disease rates linked with this syndrome. One possible factor contributing to MetS risk is changes in microbiome composition. Approximately 100 trillion bacteria and other microbes reside in the human intestinal tract, collectively termed the gut microbiome. Humans and microbes share a long evolutionary history, with many of these microbes influencing human health outcomes. However, environmental conditions have changed dramatically with human technological innovations; many of these changes (e.g., diets high in processed foods and sedentary lifestyles) appear to impact human-microbe relationships. In general, recent changes in diet and activity patterns have been linked to decreased microbiome diversity, elevating inflammation and metabolic disease risk and likely promoting the development of MetS. Targeting patient diet or exercise patterns may therefore help doctors better treat patients suffering from MetS. Still, additional work is needed to determine how the microbiome responds to changes in patient activity and diet patterns across culturally and biologically diverse human populations.

中文翻译:

代谢综合症与微生物组之间的联系

代谢综合症(MetS)是一类有害疾病,它们同时发生,例如胰岛素抵抗,腹部肥胖和高血压。全球MetS流行率迅速增长,据一些估计表明,全球有超过10亿人经历与该综合征相关的道德和疾病发生率上升。导致MetS风险的一种可能因素是微生物组组成的变化。大约100万亿细菌和其他微生物存在于人体肠道中,统称为肠道微生物组。人类和微生物有着悠久的进化历史,其中许多微生物都会影响人类健康。但是,随着人类技术的创新,环境条件发生了巨大变化。其中许多变化(例如,高加工食品饮食和久坐的生活方式似乎影响人与微生物的关系。通常,饮食和活动方式的最新变化与微生物组多样性降低,炎症和代谢疾病风险增加以及可能促进MetS的发展有关。因此,针对患者的饮食或运动方式可能有助于医生更好地治疗患有MetS的患者。但是,还需要进行额外的工作来确定微生物组如何响应文化和生物学上不同人群的患者活动和饮食模式的变化。因此,针对患者的饮食或运动方式可能有助于医生更好地治疗患有MetS的患者。尽管如此,还需要进行其他工作来确定微生物组如何响应文化和生物学上不同人群的患者活动和饮食方式的变化。因此,针对患者的饮食或运动方式可能有助于医生更好地治疗患有MetS的患者。但是,还需要进行额外的工作来确定微生物组如何响应文化和生物学上不同人群的患者活动和饮食模式的变化。
更新日期:2020-02-19
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