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Spot the Difference: Function versus Toxicity in Amyloid Fibrils.
Trends in Biochemical Sciences ( IF 13.8 ) Pub Date : 2020-05-03 , DOI: 10.1016/j.tibs.2020.04.007 Sabine M Ulamec 1 , Sheena E Radford 1
中文翻译:
找出差异:淀粉样蛋白原纤维的功能与毒性。
更新日期:2020-05-03
Trends in Biochemical Sciences ( IF 13.8 ) Pub Date : 2020-05-03 , DOI: 10.1016/j.tibs.2020.04.007 Sabine M Ulamec 1 , Sheena E Radford 1
Affiliation
In a recent study, Hervas et al. extracted Orb2 fibrils, that are involved in long-term memory formation, from Drosophila brains, characterised their function, and determined their structure using cryo-electron microscopy (cryo-EM). The fibrils show a remarkable resemblance to amyloid β (Aβ) fibrils associated with Alzheimer’s disease, highlighting the subtle difference between functional and dysfunctional amyloid.
中文翻译:
找出差异:淀粉样蛋白原纤维的功能与毒性。
在最近的一项研究中,Hervas等人。从果蝇大脑中提取的参与长期记忆形成的 Orb2 原纤维,表征了它们的功能,并使用冷冻电子显微镜 (cryo-EM) 确定了它们的结构。这些原纤维与与阿尔茨海默病相关的淀粉样蛋白 β (Aβ) 原纤维非常相似,突出了功能性淀粉样蛋白和功能失调性淀粉样蛋白之间的细微差别。