The role of several risk factors, such as pollution, consumption of alcohol, age, sex and obesity in cancer progression is undeniable. Human malignancies are mainly characterized by deregulation of cyclin-dependent kinases (CDK) and cyclin inhibitor kinases (CIK) activities. Viruses express some onco-proteins which could interfere with CDK and CIKs function, and induce some signals to replicate their genome into host’s cells. By reviewing some studies about the function of CDK and CIKs in cells infected with oncoviruses, such as HPV, HTLV, HERV, EBV, KSHV, HBV and HCV, we reviewed the mechanisms of different onco-proteins which could deregulate the cell cycle proteins.

中文翻译：

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病毒相关癌症中的细胞周期蛋白依赖性激酶和 CDK 抑制剂

不可否认，污染、饮酒、年龄、性别和肥胖等多种风险因素在癌症进展中的作用是不可否认的。人类恶性肿瘤的主要特征是细胞周期蛋白依赖性激酶 (CDK) 和细胞周期蛋白抑制剂激酶 (CIK) 活性的失调。病毒表达一些致癌蛋白，这些致癌蛋白会干扰 CDK 和 CIK 的功能，并诱导一些信号将其基因组复制到宿主细胞中。通过回顾一些关于 CDK 和 CIKs 在感染 HPV、HTLV、HERV、EBV、KSHV、HBV 和 HCV 等癌病毒的细胞中的功能的研究，我们回顾了不同癌蛋白可以解除细胞周期蛋白调节的机制。