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Regulatory T cells in skin injury: At the crossroads of tolerance and tissue repair.
Science Immunology ( IF 24.8 ) Pub Date : 2020-05-01 , DOI: 10.1126/sciimmunol.aaz9631
Ian C Boothby 1, 2 , Jarish N Cohen 3 , Michael D Rosenblum 1
Affiliation  

Skin injury is a highly inflammatory process that is carefully regulated to mitigate tissue damage and allow for proper barrier repair. Regulatory T cells (Tregs) are crucial coordinators of the immune response to injury in several organs. Here, we review the emerging role of Tregs in facilitating skin repair after injury. We focus on recently discovered interactions between lymphocytes and nonhematopoietic cells during wound healing and discuss how these interactions are regulated both by "classical" suppressive mechanisms of Tregs and by "nonclassical" reparative Treg functions.

中文翻译:

皮肤损伤中的调节性T细胞:在耐受性和组织修复的十字路口。

皮肤损伤是高度发炎的过程,需要仔细调节以减轻组织损伤并进行适当的屏障修复。调节性T细胞(Tregs)是几个器官对损伤的免疫反应的关键协调者。在这里,我们回顾了Tregs在促进损伤后皮肤修复中的新兴作用。我们专注于伤口愈合过程中淋巴细胞和非造血细胞之间最近发现的相互作用,并讨论如何通过“经典”抑制Treg机制和“非经典”修复性Treg功能调节这些相互作用。
更新日期:2020-05-01
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