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Brain-transportable soy dipeptide, Tyr-Pro, attenuates amyloid β peptide25-35-induced memory impairment in mice.
npj Science of Food ( IF 6.4 ) Pub Date : 2020-05-01 , DOI: 10.1038/s41538-020-0067-3
Mitsuru Tanaka 1 , Hayato Kiyohara 1 , Atsuko Yoshino 1 , Akihiro Nakano 1 , Fuyuko Takata 2 , Shinya Dohgu 2 , Yasufumi Kataoka 2 , Toshiro Matsui 1
Affiliation  

In this study, experiments on amyloid β peptide25-35-induced mice were performed to provide in vivo evidence on the potential of the blood-brain barrier transportable soy dipeptide, Tyr-Pro, in combating memory impairment. We demonstrated for the first time that oral administration of Tyr-Pro (100 mg/kg, twice a day) in mice for 16 days significantly improved impaired memory by spontaneous alternation and shortened step-through latency in amyloid β-induced mice.

中文翻译:

脑可运输的大豆二肽Tyr-Pro减轻了淀粉样蛋白β25-35诱导的小鼠记忆障碍。

在这项研究中,对β-淀粉样蛋白25-35诱导的小鼠进行了实验,以提供体内证据证明血脑屏障可运输的大豆二肽Tyr-Pro在对抗记忆力损伤方面的潜力。我们首次证明,在小鼠中口服Tyr-Pro(100 mg / kg,每天两次),持续16天可通过自发交替显着改善受损的记忆,并缩短淀粉样β诱导小鼠的逐步潜伏期。
更新日期:2020-05-01
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