Abstract When overexposed to ultraviolet B (UVB) irradiation, skin can cause a series of abnormal reactions, such as excessive pigmentation and solar elastosis. In order to better treat the skin after overexposed to UVB, we designed a dissolving microneedles (MNs) loading hydrophilic ascorbic acid and hydrophobic vitamin A palmitate to achieve codelivery. Here, we confirmed that MNs had enough mechanical strength to insert the skin and two drugs were delivered subcutaneously in sequence in vitro. In white guinea pigs, surface observation and histological observation results confirmed that two drugs by MNs transdermal delivery were better than topical administration in the treatment of UVB-damaged skin. The MNs provide a method of loading different drugs into the needles and advance the development of transdermal drug delivery.

中文翻译：

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用于治疗皮肤色素沉着的微针贴片中亲水性和疏水性药物的共同递送

摘要 当过度暴露于紫外线 B (UVB) 照射下时，皮肤会引起一系列异常反应，如色素沉着过多和日光性弹性组织增生。为了在过度暴露于 UVB 后更好地治疗皮肤，我们设计了一种溶解微针 (MNs)，负载亲水性抗坏血酸和疏水性维生素 A 棕榈酸酯以实现共递送。在这里，我们证实了 MNs 具有足够的机械强度来插入皮肤，并且两种药物在体外依次皮下给药。在白豚鼠中，表面观察和组织学观察结果证实，两种药物通过MNs透皮给药治疗UVB损伤皮肤的效果优于局部给药。MNs 提供了一种将不同药物装入针头的方法，并促进了透皮给药的发展。