Dobutamine is routinely used to improve cardiovascular function in anaesthetized horses. However, dobutamine in conscious horses is insufficiently investigated. Ten research horses that were already instrumented for a preceding trial were included into the study. Cardiovascular variables were recorded and blood samples taken after instrumentation (Baseline), before starting dobutamine and after 10 min of dobutamine infusion (2 µg kg⁻¹ min⁻¹). A significant increase in systemic blood pressure, mean pulmonary artery pressure and right atrial pressure, and a decrease in heart rate were observed with dobutamine compared with baseline measurements. Arterial and mixed venous haemoglobin and oxygen content, as well as mixed venous partial pressure of oxygen increased. No significant changes in cardiac output, stroke volume, systemic vascular resistance, arterial partial pressure of oxygen, or oxygen consumption, delivery and extraction ratio were detected.

中文翻译：

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多巴酚丁胺对站立式马的心血管功能和氧气输送的影响。

多巴酚丁胺通常用于改善麻醉马的心血管功能。但是，对有意识的马中的多巴酚丁胺的研究不足。这项研究包括了十个已经为先前的试验准备好的研究马。记录心血管变量并在仪器（基线）后，开始使用多巴酚丁胺之前和输注多巴酚丁胺10分钟后（2 µg kg ^-1  min ^-1）。与基线测量值相比，多巴酚丁胺观察到全身血压，平均肺动脉压和右心房压显着升高，心率降低。动脉和混合静脉血红蛋白和氧气含量以及混合静脉的氧气分压增加。没有发现心输出量，中风量，全身血管阻力，氧气动脉分压或氧气消耗，输送和提取率的显着变化。