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The responses of metabolic rate and neuropeptides to food deprivation in striped hamsters (Cricetulus barabensis) with different basal metabolic rate.
Journal of Experimental Zoology Part A ( IF 2.8 ) Pub Date : 2020-04-21 , DOI: 10.1002/jez.2362
Jing Wen 1, 2 , Qing-Sheng Chi 1 , De-Hua Wang 1, 2 , Zhi-Jun Zhao 1, 3
Affiliation  

High basal metabolic rate (BMR) is related to a powerful metabolic engine even under food shortage, which can lead to high levels of daily energy expenditure and requires more energy for maintenance in small mammals. To test the hypothesis that animals with different BMR levels respond differently to food shortage, we compared the changes in metabolism, morphology, and gene expression in response to food deprivation (FD) in male‐striped hamsters (Cricetulus barabensis) with low (L)‐ or high (H)‐BMR levels. After 36 hr of FD, energy expenditure, metabolic rate (MR), mass of body composition, and leptin and agouti‐related peptide gene expressions in the white adipose tissues and the hypothalamus, respectively, decreased significantly in hamsters. The energy expenditure of H‐BMR hamsters was reduced more than that of L‐BMR hamsters after 36 hr of FD. Furthermore, MR was significantly reduced by FD, and that of the H‐BMR group decreased more than that of the L‐BMR group during the daytime. Therefore, our data suggest that striped hamsters with different BMR display different responses to variations in food availability. During FD, MR in H‐BMR hamsters was more flexible than that in L‐BMR animals and L‐BMR hamsters could not reduce their MR any lower.

中文翻译:

不同基础代谢率的条纹仓鼠(Cicetulus barabensis)的代谢速率和神经肽对食物缺乏的响应。

即使在食物短缺的情况下,高基础代谢率(BMR)也与强大的代谢引擎有关,这可能导致高水平的日常能量消耗,并需要更多能量来维持小型哺乳动物的生命。为了检验不同BMR水平的动物对食物短缺的反应不同的假设,我们比较了雄性条纹仓鼠(Cricetulus barabensis)对食物缺乏(FD)的代谢,形态和基因表达的变化)(低(L)‐或高(H)‐BMR水平)。FD后36小时,仓鼠的白色脂肪组织和下丘脑中的能量消耗,代谢率(MR),身体组成质量以及瘦素和刺鼠相关肽基因表达分别显着降低。FD 36小时后,H-BMR仓鼠的能量消耗比L-BMR仓鼠减少的更多。此外,FD使MR显着降低,白天,H-BMR组的MR降低程度大于L-BMR组。因此,我们的数据表明,具有不同BMR的条纹仓鼠对食物供应量的变化表现出不同的反应。在FD期间,H-BMR仓鼠的MR比L-BMR动物更灵活,L-BMR仓鼠无法降低其MR。
更新日期:2020-04-21
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