Brain signals such as electroencephalography (EEG) and electrocorticography (ECoG) are used to diagnose epilepsy. ECoG signals are small and therefore require large amplification while keeping the recording electronics small enough to adapt to the surface of the brain. Moreover, the components have to be of low power to reduce the risk of brain damage while recording the brain. Herein, a neuroamplifier that is integrated in an ECoG is described. The amplifier, in combination with a novel multiplexing system that reduces the number of required amplifiers and ensures the flexibility of the ECoG, achieves the desired signal‐to‐noise ratio while reducing power consumption. The feasibility of the proposed design is validated though electronic simulations for different input signals, analyzing the actual amplification achieved and the response times. Moreover the circuit is implemented and real measurements are provided validating the simulations.

中文翻译：

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使用柔性和生物相容性技术的用于皮层脑电图的植入式神经放大器

脑电信号（如脑电图（EEG）和皮质电图（ECoG））可用于诊断癫痫病。ECoG信号很小，因此需要大放大倍数，同时又要使记录电子设备足够小，以适应大脑表面。此外，这些组件必须具有低功耗，以减少在记录大脑时大脑受损的风险。在此，描述了集成在ECoG中的神经放大器。该放大器与新颖的多路复用系统相结合，可减少所需放大器的数量并确保ECoG的灵活性，从而在降低功耗的同时实现了所需的信噪比。通过对不同输入信号进行电子仿真，分析实际实现的放大率和响应时间，验证了所提出设计的可行性。