The present communication reports the synthesis of silver‐containing bioactive glass by sol‐gel route, followed by fabrication of the antibacterial bioactive glass nanofibers (ABGnf, dia 200‐900 nm) using electrospinning technique. The ABGnf of composition 1‐2 mol% of B₂O₃, 68‐69 mol% of SiO₂, ~1 × 10⁻³ mol% of Ag₂O, and 29‐30 mol% of CaO was evaluated both for wound‐healing potential and for antibacterial efficacy. An in vitro cell proliferation/migration assay was performed using SV‐transformed GM00637 (skin fibroblast) cell line, wherein ABGnf exhibited significant cell proliferation (82%) compared to the control (47%) and ABGnf without boron (65%) in a period of 24 hours, thus establishing its wound‐healing potential. Further, the antibacterial activity was assessed in vitro using the bacterial strain of Staphylococcus aureus. The results showed the zone of inhibition to be almost two times the control group treated with a model aminoglycoside antibiotic, tobramycin. In addition to the above advantages, the in vitro cytotoxicity assay showed an excellent cellular response. All these results have established promising wound healing and antibacterial potential of ABGnf.

中文翻译：

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抗菌生物活性玻璃纳米纤维在伤口愈合中的应用前景：体外研究

本通讯报道了通过溶胶凝胶法合成含银生物活性玻璃，然后使用静电纺丝技术制造了抗菌生物活性玻璃纳米纤维（ABGnf，直径200-900 nm）。组成的ABGnf为B ₂ O _3的1-2 mol％，SiO _2的68-69  mol％，Ag _2的〜1×10 ^-3 mol％评估了O和29-30 mol％的CaO的伤口愈合潜力和抗菌功效。使用SV转化的GM00637（皮肤成纤维细胞）细胞系进行了体外细胞增殖/迁移测定，其中与对照组（47％）和不含硼的ABGnf（65％）相比，ABGnf表现出显着的细胞增殖（82％）。 24小时，从而建立了伤口愈合的潜力。此外，使用金黄色葡萄球菌的细菌菌株在体外评估抗菌活性。结果显示，用模型氨基糖苷类抗生素妥布霉素治疗的抑制区几乎是对照组的两倍。除了上述优点外，体外细胞毒性试验还显示了出色的细胞反应。所有这些结果已经建立了有希望的ABGnf伤口愈合和抗菌潜力。