The properties and use of liquid non‐aqueous phospholipid concentrates (NAPC) are reviewed. They are mainly used to solubilize poorly water‐soluble drug substances to enhance their oral bioavailability, but they also find applicability in dietetics and cosmetics. Due to the large‐scale availability of these concentrates at good manufacturing practice quality including Drug Master File (DMF) documentation, they can be used for pre‐clinical screening and clinical testing and as market form, as demonstrated by the product of Wyeth/Pfizer, Rapamune, enabling a cost effective and fast dosage form development. When needed, NAPC can be converted to solid dosage forms by means of a capsule fill or addition of adsorbing excipients. It is concluded that NAPC deserve more attention and a broader use in the life science industry.

中文翻译：

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非水性磷脂浓缩物，可提高难溶化合物的生物利用度

回顾了液体非水磷脂浓缩物（NAPC）的性质和用途。它们主要用于溶解水溶性差的药物，以增强其口服生物利用度，但它们也可用于饮食和化妆品。由于这些浓缩物具有良好的生产实践质量，包括药物主文件（DMF）文档，因此可以大规模使用，因此它们可以用于临床前筛查和临床测试，并且可以作为市场形式使用，如Wyeth / Pfizer产品所示Rapamune，可实现具有成本效益的快速剂型开发。需要时，可以通过胶囊填充或添加吸附性赋形剂将NAPC转化为固体剂型。结论是，NAPC在生命科学行业中应引起更多关注并得到更广泛的应用。