Autoimmune pancreatitis, a derivative of chronic pancreatitis, frequently causes acute episodes with clinical symptoms parallel to those of acute pancreatitis. Corticosteroids are effective in the treatment of 90% of autoimmune pancreatitis cases, but for the remaining 10%, options are limited. Due to their significant immunomodulatory capabilities, mesenchymal stromal cells (MSCs) have been proposed as a novel treatment strategy for various immune and inflammatory pathologies including those with autoimmune origins. Here, we not only highlight the most recent MSC live‐cell experiments to address acute pancreatitis, but also discuss the opportunities afforded by the emergence of the newly identified field of MSC necrobiology. We conclude that the putative employment of MSC derivatives provides a newer and simpler therapeutic approach that could have significant advantages over the use of cells themselves.

中文翻译：

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间充质基质细胞及其衍生物-自身免疫性胰腺炎管理中的推定疗法。

自身免疫性胰腺炎是慢性胰腺炎的一种衍生物，经常引起急性发作，其临床症状与急性胰腺炎的症状平行。皮质类固醇可有效治疗90％的自身免疫性胰腺炎，但对于其余10％的患者，选择范围有限。由于其显着的免疫调节能力，间质基质细胞（MSCs）已被提议作为一种针对各种免疫和炎性病理（包括具有自身免疫起源的病理）的新型治疗策略。在这里，我们不仅重点介绍了针对急性胰腺炎的最新MSC活细胞实验，而且还讨论了新发现的MSC坏死生物学领域带来的机遇。