The micropore structure is prerequisite for fast and durable endothelialization of artificial small diameter blood vessels (ASDBVs). Although some methods, such as salt leaching, coagulation, and electrospinning, have been developed to construct micropores for ASDBVs, the uncontrollability of the structure and the complicated procedures of the process are still the issues to be concerned about. In this study, a compact device based on the principle of centrifugal force is established and used to prepare polyurethane (PU) ASDBVs with micropore structures by blasting different porogens. It is found that the glass beads could construct micropores with regular round shape, uniform distribution, and controllable size (60–350 µm), which significantly improves the endothelialization of PU‐based ASDBVs, especially when the pore size is about 60 µm. This method is easy‐accessible and wide‐applicable, which provides a new pathway for the research and development of ASDBVs.

中文翻译：

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离心力诱导微孔结构可控的小直径血管改善内皮化

微孔结构是人工小直径血管 (ASDBV) 快速持久内皮化的先决条件。尽管已经开发了盐浸、混凝和静电纺丝等方法来构建ASDBVs微孔，但结构的不可控性和工艺过程的复杂性仍然是需要关注的问题。在这项研究中，建立了一种基于离心力原理的紧凑装置，并用于通过爆破不同的致孔剂制备具有微孔结构的聚氨酯 (PU) ASDBV。发现玻璃珠可以构建规则圆形、分布均匀、尺寸可控（60-350 μm）的微孔，显着提高了基于聚氨酯的ASDBVs的内皮化，尤其是当孔径约为60 μm时。