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Trace elements homeostasis in brain exposed to 900 MHz RFW emitted from a BTS-antenna model and the protective role of vitamin E.
Journal of Animal Physiology and Animal Nutrition ( IF 2.7 ) Pub Date : 2020-04-12 , DOI: 10.1111/jpn.13360
Mansour Azimzadeh 1 , Gholamali Jelodar 1
Affiliation  

Advances in telecommunication and their broad usage in the community have become a great concern from the health aspect. The object of the present study was to examine the effects of exposure to 900 MHz RFW on brain Iron (Fe), Copper (Cu), Zinc (Zn) and Manganese (Mn) concentration, and the protective role of pre‐treatment of vitamin E on mentioned elements homoeostasis. Twenty adult male Sprague–Dawley rats (200 ± 20 g) randomly were divided into four groups. Control group (without any exposure, received distilled water), treatment control group (orally received 250 mg/kg BW/d vitamin E), treatment group (received 250 mg/kg BW/d vitamin E and exposed to 900 MHz RFW) and sham‐exposed group (exposed to 900 MHz RFW). Animals (with freely moving in the cage) were exposed to RFW for 30 consecutive days (4 hr/day). The levels of the above mentioned elements in the brain tissue were determined on the last day using atomic absorption spectrophotometry. Exposure to 900 MHz RFW induced a significant increase in the Fe, Cu, Mn levels and Cu/Zn ratio accompanied by a significant decrease in Zn level in the sham‐exposed group compare to control group. Vitamin E pre‐treatment improved the level of Fe, Cu, Mn and Cu/Zn ratio, except in the Zn concentration. Exposure to 900 MHz RFW caused disrupted trace elements homoeostasis in the brain tissue and administration of vitamin E as an antioxidant and neuroprotective agent improved the situation.

中文翻译:

暴露于BTS天线模型发射的900 MHz RFW的大脑中的微量元素稳态和维生素E的保护作用。

从健康的角度来看,电信的发展及其在社区中的广泛使用已成为人们高度关注的问题。本研究的目的是研究900 MHz RFW暴露对脑铁(Fe),铜(Cu),锌(Zn)和锰(Mn)浓度的影响以及维生素预处理的保护作用E上提到的元素同源性。将20只成年雄性Sprague–Dawley大鼠(200±20 g)随机分为四组。对照组(无任何暴露,接受蒸馏水),治疗对照组(口服,接受250 mg / kg BW / d维生素E),治疗组(接受250 mg / kg BW / d维生素E,并暴露于900 MHz RFW)和假暴露组(暴露于900 MHz RFW)。使动物(在笼中自由移动)连续30天(4小时/天)暴露于RFW。使用原子吸收分光光度法在最后一天确定脑组织中上述元素的水平。与对照组相比,假暴露组暴露于900 MHz RFW会导致Fe,Cu,Mn含量和Cu / Zn比值显着增加,同时Zn含量显着下降。维生素E预处理可以改善铁,铜,锰和铜/锌比的水平,但锌的浓度除外。暴露于900 MHz RFW会破坏大脑组织中的痕量元素同源性,使用维生素E作为抗氧化剂和神经保护剂可以改善这种情况。与对照组相比,假暴露组中的锰水平和铜锌比显着降低。维生素E预处理可改善铁,铜,锰和铜/锌比的水平,但锌的浓度除外。暴露于900 MHz RFW会破坏脑组织中的痕量元素同源性,使用维生素E作为抗氧化剂和神经保护剂可以改善这种情况。与对照组相比,假暴露组中的锰水平和铜锌比显着降低。维生素E预处理可改善铁,铜,锰和铜/锌比的水平,但锌的浓度除外。暴露于900 MHz RFW会破坏脑组织中的痕量元素同源性,使用维生素E作为抗氧化剂和神经保护剂可以改善这种情况。
更新日期:2020-04-12
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