The present trial was conducted to evaluate the beneficial role of some feed additives (potassium sorbate; Sor, hydrated sodium calcium almuniosilicate; Hsc and l‐methionine; L‐M) in attenuating the hepatic and renal toxicity of aflatoxin B1 (AFB1) in rabbits. A total number of 72 NZW growing rabbits (5 week‐old) were divided into six experimental groups (four replicates with three rabbits each) as follows: control group, AFB1 group (supplemented with AFB1 0.3 mg/kg diet), AFB1 + Sor group (AFB1 0.3 mg/kg diet + Sor 2 g/kg diet), AFB1 + Hsc group (AFB1 0.3 mg/kg diet + Hsc 5 g/kg diet), AFB1 + L‐M group (AFB1 0.3 mg/kg diet + L‐M 8 g/kg diet) and AFB1 + Mix group (AFB1 0.3 mg/kg diet + 2 Sor + 5 Hsc + 8 L‐M g/kg diet). Serum levels of total protein, albumin and globulin were significantly reduced by AF. AF increased the serum activity of aspartate aminotransferase (AST), alanine amino transferase (ALT) and alkaline phosphatase (ALP) enzymes. While, they were reduced in AF + Sor and AF + Mix groups compared with AF group. AF increased the level of cystatin C and Beta‐2 microglobulin (BMG). All other supplements significantly reduced the level of cystatin C than AF; however, this reduction was more pronounced in AF‐L‐M group. AF + Sor, AF + L‐M and AF + Mix equally reduced the BMG level than AF and AF + HSc, however, still higher than control. AF elevated the total cholesterol (TC) and LDL‐cholesterol levels. A significant reduction in HDL cholesterol was seen in AF group. Additionally, AF induced pathological alterations in the liver and kidney of exposed rabbits on the other hands, the three additives separately or in mix attenuated the Af‐induced alterations. In conclusion, the dietary supplementation of Sor, L‐M, Hsc or their mixture was effective in ameliorating the negative effects of AFB1 on liver and kidney function and structure in rabbits with more better improvement obtained by Sor or L‐M separately.

中文翻译：

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某些饲料添加剂减轻黄曲霉毒素B1对家兔肝肾损害的功效。

进行本试验是为了评估某些饲料添加剂（山梨酸钾； Sor，水合钠铝硅酸钠钙； Hsc和l蛋氨酸 L-M）减轻黄曲霉毒素B1（AFB1）对家兔的肝肾毒性。将总共​​72头生长在NZW的兔子（5周龄）分为六个实验组（四个重复，每个重复三只兔子），如下：对照组，AFB1组（补充0.3 mg / kg的AFB1日粮），AFB1 + Sor组（AFB1 0.3 mg / kg饮食+ Sor 2 g / kg饮食），AFB1 + Hsc组（AFB1 0.3 mg / kg饮食+ Hsc 5 g / kg饮食），AFB1 + L‐M组（AFB1 0.3 mg / kg饮食） + L‐M 8 g / kg饮食）和AFB1 +混合组（AFB1 0.3 mg / kg饮食+ 2 Sor + 5 Hsc + 8 L‐M g / kg饮食）。AF可使血清总蛋白，白蛋白和球蛋白水平显着降低。AF增加了血清天冬氨酸转氨酶（AST），丙氨酸转氨酶（ALT）和碱性磷酸酶（ALP）的活性。而，与AF组相比，AF + Sor和AF + Mix组的体重降低。AF可增加胱抑素C和Beta-2微球蛋白（BMG）的水平。与AF相比，所有其他补品均能显着降低胱抑素C的水平。但是，这种减少在AF‐L‐M组中更为明显。AF + Sor，AF + L‐M和AF + Mix与AF和AF + HSc相比，降低了BMG的水平，但仍高于对照。AF升高了总胆固醇（TC）和LDL-胆固醇水平。在AF组中，HDL胆固醇显着降低。此外，另一方面，AF可以引起裸露兔子的肝脏和肾脏病理变化，三种添加剂分别或混合使用可以减弱Af引起的变化。总之，Sor，LM，