In this study, we examined the effects of acute intravenous administration of l‐arginine on circulating levels of metabolites in the portal‐drained viscera (PDV) of 12 barrows surgically fitted with chronic catheters in the portal vein. At day 14 post‐surgery, the pigs were fasted for 12 hr and then randomly allocated to one of three groups to receive administration of normal saline, l‐alanine [103 mg/kg body weight (BW), isonitrogenous control] or l‐arginine‐HCl (61 mg/kg BW), via the portal vein. Blood samples were obtained from the carotid artery before and at 30‐min intervals for 5 hr after the administration of saline or amino acid in order to determine metabolic profiles. The results showed that, compared with the saline treatment, arginine infusion increased plasma concentrations of insulin‐like growth factor‐I, arginine and cystine in the portal vein plasma, whereas plasma concentrations of threonine, serine, leucine and methionine were reduced. These findings indicate that increasing arginine concentrations in the portal vein alters the metabolic profile in swine, an established animal model for studying human nutrition and metabolism.

中文翻译：

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急性施用l-精氨酸的肥育猪门静脉内脏中代谢产物循环水平的动态变化。

在这项研究中，我们检查了急性精氨酸静脉注射l-精氨酸对通过外科手术在门静脉中装有慢性导管的12头猪的门静脉内脏（PDV）代谢产物循环水平的影响。手术后第14天，将猪禁食12小时，然后随机分为三组之一接受生理盐水，l-丙氨酸[103 mg / kg体重（BW），等氮质控]或l精氨酸-HCl（61 mg / kg体重），通过门静脉。在注射生理盐水或氨基酸之前和之后30分钟间隔30分钟从颈动脉采集血样，以确定代谢曲线。结果表明，与盐水处理相比，精氨酸输注增加了门静脉血浆中胰岛素样生长因子-I，精氨酸和胱氨酸的血浆浓度，而苏氨酸，丝氨酸，亮氨酸和蛋氨酸的血浆浓度降低。这些发现表明，门静脉中精氨酸浓度的增加会改变猪的代谢谱，这是研究人类营养和代谢的公认动物模型。