The aldose reductase inhibitory activity of extracts from Rosa hybrida petals was evaluated, and a bioactive flavonoid, kaempferol, was isolated from petals via bioassay-guided isolation. Kaempferol was isolated from the ethyl acetate fraction of R. hybrida and was shown to exhibit strong inhibition against aldose reductase (IC50 = 0.02 µM). Quantitative analyses of kaempferol in R. hybrida petals, different flower parts, and different Rosa species were also performed using high-performance liquid chromatography. This study is the first to establish that R. hybrida contains kaempferol and that the light-pink petals of this edible rose species exhibit the highest content of the naturally occurring aldose reductase inhibitor. The results of this study suggested the potential role of R. hybrida petals in the treatment and management of diabetic complications via aldose reductase inhibition.

中文翻译：

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蔷薇花瓣及其活性成分山奈酚的醛糖还原酶抑制作用

评价了蔷薇花瓣提取物的醛糖还原酶抑制活性，并通过生物测定引导的分离从花瓣中分离出具有生物活性的黄酮类化合物山奈酚。Kaempferol 从 R. hybrida 的乙酸乙酯级分中分离出来，并显示出对醛糖还原酶的强烈抑制作用 (IC50 = 0.02 µM)。还使用高效液相色谱对 R. hybrida 花瓣、不同花部分和不同 Rosa 物种中的山奈酚进行了定量分析。这项研究首次确定了 R. hybrida 含有山奈酚，并且这种可食用玫瑰品种的浅粉色花瓣表现出最高含量的天然醛糖还原酶抑制剂。这项研究的结果表明 R 的潜在作用。