Genome editing enables very accurate alterations to DNA. It promises profound and potentially disruptive changes in healthcare, agriculture, industry, and the environment. This paper presents a multidisciplinary analysis of the contemporary development of genome editing and the tension between continuity and change. It draws on the idea that actors involved in innovation are guided by “sociotechnical regimes” composed of practices, institutions, norms, and cultural beliefs. The analysis focuses on how genome editing is emerging in different domains and whether this marks continuity or disruption of the established biotechnology regime. In conclusion, it will be argued that genome editing is best understood as a technology platform that is being powerfully shaped by this existing regime but is starting to disrupt the governance of biotechnology. In the longer term is it set to converge with other powerful technology platforms, which together will fundamentally transform the capacity to engineer life.

中文翻译：

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基因组编辑：生命工程中连续性、融合和变化的动力学

基因组编辑可以非常准确地改变 DNA。它有望在医疗保健、农业、工业和环境方面带来深刻且潜在的破坏性变化。本文对基因组编辑的当代发展以及连续性与变化之间的张力进行了多学科分析。它借鉴了这样一种观点，即参与创新的参与者受由实践、制度、规范和文化信仰组成的“社会技术制度”的指导。该分析侧重于基因组编辑如何在不同领域出现，以及这是否标志着已建立的生物技术制度的连续性或破坏性。总而言之，人们认为基因组编辑最好被理解为一种技术平台，该平台正在受到现有制度的有力塑造，但开始破坏生物技术的治理。