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Inevitable role of TGF-β1 in progression of nonalcoholic fatty liver disease
Journal of Receptors and Signal Transduction ( IF 2.8 ) Pub Date : 2020-02-13 , DOI: 10.1080/10799893.2020.1726952
Bhagyalakshmi Nair 1 , Lekshmi R. Nath 1
Affiliation  

Abstract Nonalcoholic fatty liver disease (NAFLD) is a major health concern and the most commonly diagnosed chronic liver manifestation among 25% worldwide population. Obesity, insulin resistance, accumulation of toxic lipid free radicals, generation of oxidative stress, overconsumption of fat containing dietary meals and lack of exercise are the paramount factors accountable for the development of NAFLD. During NAFLD, increased oxidative stress and production of enormous number of toxic free radicals activates a number of pro-inflammatory and inflammatory pathways. TGF-β signaling mechanisms play a central role in maintaining the normal homeostasis of liver. TGF-β1, one of the three isoforms of TGF-β family has significant role in different stages of chronic liver conditions. TGF-β1 promotes HSC activation and extracellular matrix production (ECM), which further contributes in the progression of NAFLD. In this review, we outline the role of TGF-β1 in different phases of progressive NAFLD along with the signaling mechanism. Graphical Abstract

中文翻译:

TGF-β1 在非酒精性脂肪性肝病进展中的必然作用

摘要 非酒精性脂肪性肝病 (NAFLD) 是一个主要的健康问题,也是全球 25% 人口中最常诊断出的慢性肝脏表现。肥胖、胰岛素抵抗、有毒脂质自由基的积累、氧化应激的产生、含脂肪饮食的过度消耗和缺乏运动是导致 NAFLD 发展的首要因素。在 NAFLD 期间,氧化应激增加和大量有毒自由基的产生激活了许多促炎和炎症途径。TGF-β 信号传导机制在维持肝脏的正常稳态中起着核心作用。TGF-β1 是 TGF-β 家族的三种同工型之一,在慢性肝病的不同阶段具有重要作用。TGF-β1 促进 HSC 活化和细胞外基质产生 (ECM),这进一步促进了 NAFLD 的进展。在这篇综述中,我们概述了 TGF-β1 在进行性 NAFLD 不同阶段的作用以及信号传导机制。图形概要
更新日期:2020-02-13
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