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Post-glacial phylogeography and variation in innate immunity loci in a sylvatic rodent, bank vole Myodes glareolus
Mammalian Biology ( IF 1.6 ) Pub Date : 2020-03-06 , DOI: 10.1007/s42991-020-00016-y
Agnieszka Kloch , Aleksandra Biedrzycka

In the northern hemisphere, the spatial structure of many taxa has been shaped by migration patterns after the last glaciation, and phylogeography based on mtDNA variation may reflect the post-glacial demography. The mtDNA lineages are expected to differ in their adaptations to local conditions but little is known about the impact of these conditions on functional genetic variation. Here, we answer this question through an analysis of geographic variation and selection patterns in seven innate immunity genes in free-living bank voles Myodes glareolus from 10 localities across species range assigned to different lineages based on mtDNA. We found clear discrepancies between population structure in mtDNA and each of the studied innate immunity genes. There was no uniform pattern of spatial variation at immunity loci, they differed in the levels of polymorphism, and the results of neutrality tests were not consistent over loci. Each locus comprised a few common haplotypes shared between mitochondrial lineages and studied locations, plus numerous haplotypes unique for each studied site. Our results suggest that the diversity of innate immunity genes cannot be explained solely in terms of demographic processes, and that the observed polymorphism may be attributed to local selection. The strength and direction of selection differed between loci, even within the same gene family, which underlines how crucial it is to take a complex approach while studying the selection patterns acting on immune-related genes.

中文翻译:

冰川后系统地理学和森林啮齿动物先天免疫位点的变化,银行田鼠 Myodes glareolus

在北半球,许多分类群的空间结构已经被末次冰期后的迁徙模式所塑造,基于 mtDNA 变异的系统地理学可能反映了冰期后的人口统计学。预计 mtDNA 谱系在适应当地条件方面会有所不同,但对这些条件对功能遗传变异的影响知之甚少。在这里,我们通过分析来自基于 mtDNA 分配给不同谱系的跨物种范围的 10 个地点的自由生活银行田鼠 Myodes glareolus 的七个先天免疫基因的地理变异和选择模式来回答这个问题。我们发现 mtDNA 中的种群结构与每个研究的先天免疫基因之间存在明显差异。免疫位点没有统一的空间变异模式,它们的多态性水平不同,中性测试结果在基因座上并不一致。每个基因座都包含在线粒体谱系和研究位置之间共享的一些常见单倍型,以及每个研究位点独特的众多单倍型。我们的研究结果表明,先天免疫基因的多样性不能仅用人口统计学过程来解释,观察到的多态性可能归因于局部选择。即使在同一基因家族内,基因座之间的选择强度和方向也不同,这突显了在研究作用于免疫相关基因的选择模式时采取复杂方法的重要性。每个基因座都包含在线粒体谱系和研究位置之间共享的一些常见单倍型,以及每个研究位点独特的众多单倍型。我们的结果表明,先天免疫基因的多样性不能仅用人口统计过程来解释,观察到的多态性可能归因于局部选择。即使在同一基因家族内,基因座之间的选择强度和方向也不同,这突显了在研究作用于免疫相关基因的选择模式时采取复杂方法的重要性。每个基因座都包含在线粒体谱系和研究位置之间共享的一些常见单倍型,以及每个研究位点独特的众多单倍型。我们的结果表明,先天免疫基因的多样性不能仅用人口统计过程来解释,观察到的多态性可能归因于局部选择。即使在同一基因家族内,基因座之间的选择强度和方向也不同,这突显了在研究作用于免疫相关基因的选择模式时采取复杂方法的重要性。并且观察到的多态性可能归因于局部选择。即使在同一基因家族内,基因座之间的选择强度和方向也不同,这突显了在研究作用于免疫相关基因的选择模式时采取复杂方法的重要性。并且观察到的多态性可能归因于局部选择。即使在同一基因家族内,基因座之间的选择强度和方向也不同,这突显了在研究作用于免疫相关基因的选择模式时采取复杂方法的重要性。
更新日期:2020-03-06
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