Purpose

To study the changes in intraocular pressure (IOP) and aqueous flare in eyes with multiple evanescent white dot syndrome (MEWDS) during the disease course.

Study design

Retrospective observational study.

Methods

Twenty-one patients with unilateral MEWDS were retrospectively evaluated. IOP values were compared between the affected and fellow eyes 2 weeks, 1 month, and 3 months following disease onset in 17 patients, and within 7 days from disease onset in 11 patients. Aqueous flare values measured using a laser flare-cell meter in ten eyes between 1 weeks and 1 month from disease onset were compared between the affected and fellow eyes.

Results

IOP values were significantly lower in the affected eyes than in the fellow eyes at both 2 weeks (P=0.002) and 1 month from disease onset (P=0.02). However, IOP values of affected eyes did not show significant differences from the fellow eyes within 7 days ((P=0.11) and 3 months of onset (P=0.30). Aqueous flare values were significantly increased in the affected eyes compared to those in the fellow eyes (P=0.010) and significantly correlated with IOP values (r=−0.67, P=0.035).

Conclusion

IOP values mildly decreased in association with aqueous flare values in the acute phase in eyes with MEWDS.

中文翻译：

---

多发性白点综合征眼内眼压和房水的变化。

目的

研究在病程中多发性白点综合症（MEWDS）眼睛的眼压（IOP）和房水耀斑的变化。

学习规划

回顾性观察研究。

方法

回顾性评估21例单侧MEWDS患者。在17例患者发病后2周，1个月和3个月之间以及11例患者发病后7天内比较了患眼和同伴眼的IOP值。在患病的眼睛和另一只眼睛之间，比较了从疾病发作开始的1周到1个月之间用激光火炬细胞仪测量的10只眼睛的水亮值。

结果

在发病2周（P = 0.002）和发病1个月（P = 0.02）的情况下，患眼的IOP值均显着低于其他眼。然而，患眼的IOP值在7天内（（P = 0.11）和发病3个月（P = 0.30））与其他眼睛没有显着差异，与正常人相比，患眼的水耀斑值显着增加。另一只眼睛（P = 0.010）并与IOP值显着相关（r = −0.67，P = 0.035）。

结论

MEWDS眼急性期的IOP值与房水耀斑值轻度降低。