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Evidence of retinal anterograde neurodegeneration in the very early stages of multiple sclerosis: a longitudinal OCT study.
Neurological Sciences ( IF 3.3 ) Pub Date : 2020-04-30 , DOI: 10.1007/s10072-020-04431-4
Anna M Pietroboni 1, 2 , Tiziana Carandini 1, 2 , Laura Dell'Arti 3 , Francesca Bovis 4 , Annalisa Colombi 1, 2 , Milena A De Riz 1, 2 , Elena Casazza 5 , Elisa Scola 6 , Chiara Fenoglio 2, 5 , Andrea Arighi 1, 2 , Giorgio G Fumagalli 1, 2, 5 , Fabio Triulzi 5, 6 , Daniela Galimberti 1, 2, 5 , Francesco Viola 3, 5 , Elio Scarpini 1, 2, 5
Affiliation  

BACKGROUND Neurodegenerative processes are present since the early stages of multiple sclerosis (MS), constituting the primary substrate of disability. As part of the CNS, retinal damage could be considered a reliable prognostic biomarker of neurodegeneration in MS. OBJECTIVES To characterize longitudinal changes in the retinal layers' thickness and to investigate correlations between retinal atrophy and other prognostic biomarkers, i.e., cerebrospinal fluid (CSF) β-amyloid1-42 (Aβ) levels. METHODS Forty-two eyes without a history of optic neuritis of 23 MS patients were recruited. All patients underwent spectral-domain-OCT scans (SD-OCT), brain magnetic resonance imaging (MRI), and lumbar puncture at baseline. SD-OCT and brain MRI were repeated after 12 months. Ten controls underwent the same OCT procedure. RESULTS At baseline, macular ganglion cell/inner plexiform layer (mGCIPL) thickness was reduced in patients compared to controls (p = 0.008), without retinal nerve fiber layer (RNFL) thinning, that was revealed only at follow-up (p = 0.005). Patients with lower CSF Aβ levels displayed reduced RNFL thickness values, both at baseline and follow-up. CONCLUSIONS At very early clinical stages, mGCIPL thickness values were reduced without a concomitant peripapillary RNFL thinning. The longitudinal assessment demonstrated a RNFL loss in patients compared to HC, together with a plateau of mGCIPL thinning. Aβlow subgroup of patients showed a reduction of retinal nerve fiber layer thickness.

中文翻译:

在多发性硬化症的早期阶段,视网膜顺行神经变性的证据:一项纵向OCT研究。

背景技术自多发性硬化症(MS)的早期阶段以来就存在神经变性过程,其构成残疾的主要底物。作为中枢神经系统的一部分,视网膜损伤可以被认为是MS中神经变性的可靠预后生物标志物。目的表征视网膜层厚度的纵向变化,并研究视网膜萎缩与其他预后生物标志物,例如脑脊液(CSF)β-淀粉样蛋白1-42(Aβ)水平之间的相关性。方法招募了23例无视神经炎史的MS患者23眼。所有患者均在基线时进行了频谱域OCT扫描(SD-OCT),脑磁共振成像(MRI)和腰椎穿刺。12个月后重复SD-OCT和脑MRI。十个对照进行了相同的OCT程序。结果在基线,与对照组相比,患者的黄斑神经节细胞/内丛状层(mGCIPL)厚度减少(p = 0.008),而视网膜神经纤维层(RNFL)变薄,仅在随访时才显示(p = 0.005)。CSFAβ水平较低的患者在基线和随访时均显示出降低的RNFL厚度值。结论在非常早期的临床阶段,mGCIPL厚度值降低了,而乳周周围RNFL却没有变薄。纵向评估显示,与HC相比,患者的RNFL丢失,以及mGCIPL变薄的平台期。Aβlow亚组患者的视网膜神经纤维层厚度减少。仅在随访中才发现(p = 0.005)。CSFAβ水平较低的患者在基线和随访时均显示出降低的RNFL厚度值。结论在非常早期的临床阶段,mGCIPL厚度值降低了,而乳周周围RNFL却没有变薄。纵向评估显示,与HC相比,患者的RNFL丢失,以及mGCIPL变薄的平台期。Aβlow亚组患者的视网膜神经纤维层厚度减少。仅在随访中才发现(p = 0.005)。CSFAβ水平较低的患者在基线和随访时均显示出降低的RNFL厚度值。结论在非常早期的临床阶段,mGCIPL厚度值降低了,而乳周周围RNFL却没有变薄。纵向评估显示,与HC相比,患者的RNFL丢失,以及mGCIPL变薄的平台期。Aβlow亚组患者的视网膜神经纤维层厚度减少。以及mGCIPL稀疏的平台期。Aβlow亚组患者的视网膜神经纤维层厚度减少。以及mGCIPL稀疏的平台期。Aβlow亚组患者的视网膜神经纤维层厚度减少。
更新日期:2020-04-30
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