Genetic association studies can determine the effect size of gene loci on disease outcomes. In the arena of HBV infections, HLA alleles that associate with HBV outcomes can be used in clinical management decisions. This potential translational utility can shape the future management of HBV infections by identifying at-risk individuals and tailoring medical interventions accordingly. This precision medicine motif is currently only a nascent idea. However, it has stakes that may well override the current "wait and see" approach of clinical management of HBV infections. Here, we have identified HLA alleles associated with HBV outcome in a Ghanaian cohort. Our findings support the motif that HLA alleles associate with HBV outcome along geo-ethnic lines. This buttresses the need for further population pivoted studies. In the long term, our findings add to efforts towards the development of an HLA molecular-based algorithm for predicting HBV infection outcomes.

中文翻译：

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亮点文章：加纳队列中的乙型肝炎感染结局与新型人类白细胞抗原变异有关。

遗传关联研究可以确定基因位点对疾病结果的影响大小。在HBV感染领域，与HBV结果相关的HLA等位基因可用于临床管理决策。这种潜在的翻译实用程序可以通过识别高风险个体并相应地调整医疗干预措施，来影响HBV感染的未来管理。目前，这种精确的医学主题只是一个新生的想法。但是，它的利益可能会大大超过当前的HBV感染临床管理的“观望”方法。在这里，我们确定了加纳队列中与HBV结果相关的HLA等位基因。我们的发现支持HLA等位基因与沿地域种族关系的HBV结果相关的主题。这支持了进一步的以人口为中心的研究的需要。在长期，