Inflammation is usually considered as harmful; however, it is also necessary for tissue recovery after injury. Macrophages exert immune and nonimmune functions throughout this process. During skeletal muscle regeneration, they mount an inflammatory response while exerting trophic roles on muscle and mesenchymal stem cells. Proinflammatory macrophages shift to being anti-inflammatory, triggering the resolution of inflammation. Studies have highlighted that during this shift, a crosstalk ensues, integrating cues for resolution, efferocytosis, cellular metabolism, and signaling pathways. During the restorative phase, macrophages dampen inflammation while promoting stem cell differentiation, angiogenesis, and matrix remodeling. Since blunting the inflammatory phase can be detrimental for muscle regeneration, we suggest that rather than fighting inflammation, it should be allowed to operate and resolve, thus allowing for tissue recovery.

中文翻译：

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炎症和骨骼肌再生：留给巨噬细胞！

炎症通常被认为是有害的；但是，损伤后的组织恢复也是必要的。在整个过程中，巨噬细胞发挥免疫和非免疫功能。在骨骼肌再生过程中，它们会发炎反应，同时在肌肉和间充质干细胞上发挥营养作用。促炎性巨噬细胞转变为抗炎性，触发炎症消退。研究表明，在这种转变过程中，会发生串扰，并整合了用于分辨，胞吞作用，细胞代谢和信号通路的线索。在恢复阶段，巨噬细胞可减轻炎症，同时促进干细胞分化，血管生成和基质重塑。由于钝化炎症阶段可能有害于肌肉再生，