Progress in the identification of causal genes and understanding of the mechanism underlying kidney disease is hindered by the almost exclusive use of a few animal models with restrictive monogenic backgrounds that may be more resistant to kidney disease compared with humans and, therefore, poor models. Exploring the large genetic diversity in classical animal models, such as mice and rats, and leveraging species diversity will allow us to use the genetic advantages of zebrafish, Drosophila, and other species, to develop both new animal models that are more relevant to the study of human kidney disease and potential therapies.

中文翻译：

---

利用遗传和物种多样性来解决肾脏疾病。

几乎排他性地使用少数具有限制性单基因背景的动物模型阻碍了病因基因的识别和对肾脏疾病的潜在机制的理解，与人类相比，这些动物模型对人类肾脏疾病的抵抗力更强，因此模型较差。探索经典动物模型（例如小鼠和大鼠）中的巨大遗传多样性，并利用物种多样性，将使我们能够利用斑马鱼，果蝇和其他物种的遗传优势，开发与该研究更相关的两种新动物模型人肾脏疾病和潜在的治疗方法。