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What factors modify the effect of monthly bolus dose vitamin D supplementation on 25-hydroxyvitamin D concentrations?
The Journal of Steroid Biochemistry and Molecular Biology ( IF 4.1 ) Pub Date : 2020-04-30 , DOI: 10.1016/j.jsbmb.2020.105687
Zhenqiang Wu 1 , Carlos A Camargo 2 , Ian R Reid 3 , Angela Beros 1 , John D Sluyter 1 , Debbie Waayer 1 , Carlene M M Lawes 1 , Les Toop 4 , Kay-Tee Khaw 5 , Robert Scragg 1
Affiliation  

The increasing use of vitamin D supplements has stimulated interest in identifying factors that may modify the effect of supplementation on circulating 25-hydroxyvitamin D (25(OH)D) concentrations. Such information is of potential interest to researchers, clinicians and patients when deciding on bolus dose of vitamin D supplementation. We carried out a large randomized controlled trial of 5110 adults aged 50-84 years, of European/Other (84%), Polynesian (11%) and Asian (5%) ethnicity, to whom we gave a standard dose of vitamin D3 supplements (200,000 IU initially, then 100,000 IU monthly) which was taken with high adherence. All participants provided a baseline blood sample, and follow-up blood samples were collected at 6 months and annually for 3 years in a random sample of 441 participants, and also at 2 years in 413 participants enrolled in a bone density sub-study. Serum 25(OH)D was measured by LC/MSMS. Mixed model analyses were carried out on all 854 participants providing follow-up blood samples in multivariable models that included age, sex, ethnicity, body mass index (kg/m2), tobacco smoking, alcohol intake, physical activity, sun exposure, season, medical prescription of high-dose vitamin D3 (Cal.D.Forte tablets), asthma/COPD and the study treatment (vitamin D or placebo). The adjusted mean difference in 25(OH)D in the follow-up points between vitamin D supplementation and placebo groups was inversely related (all p for interaction <0.05) to baseline 25(OH)D, BMI, and hours of sun exposure, and higher in females, elders, and those with high frequency of alcohol, medical prescription of vitamin D, and asthma/COPD. The mean difference was not significantly related to ethnicity (p = 0.12), tobacco (p = 0.34), and vigorous activity (p = 0.33). In summary, these data show that vitamin D status, BMI, sun exposure hours, sex and asthma/COPD modify the 25(OH)D response to vitamin D supplementation. By contrast, ethnicity, tobacco smoking, and vigorous activity do not.

中文翻译:

哪些因素改变每月推注剂量维生素D对25-羟基维生素D浓度的影响?

日益增加的维生素D补充剂的使用引起了人们对确定可能改变补充剂对循环25-羟基维生素D(25(OH)D)浓度的影响的兴趣。当决定补充维生素D的剂量时,研究人员,临床医生和患者可能会对此类信息感兴趣。我们对5110名年龄在50-84岁,欧洲/其他(84%),波利尼西亚(11%)和亚洲(5%)族群的成年人进行了随机对照试验,并向他们提供了标准剂量的维生素D3补充剂(最初为200,000 IU,然后每月为100,000 IU),并且遵循率很高。所有参与者均提供了基线血液样本,并在441个参与者的随机样本中分别于6个月和每年3年中收集了随访血液样本,并且在2年时,有413名参与者参加了骨密度子研究。通过LC / MSMS测定血清25(OH)D。对所有854名参与者进行了混合模型分析,这些参与者提供了多变量模型的随访血样,包括年龄,性别,种族,体重指数(kg / m2),吸烟,饮酒,身体活动,日晒,季节,高剂量维生素D3(Cal.D.Forte片)的医疗处方,哮喘/ COPD和研究治疗药物(维生素D或安慰剂)。补充维生素D与安慰剂组之间的随访点中25(OH)D的校正平均差异与基线25(OH)D,BMI和日照时间呈负相关(相互作用的所有p <0.05),在女性,老年人和高频率饮酒,维生素D的医疗处方以及哮喘/ COPD的人群中更高。平均差异与种族(p = 0.12),烟草(p = 0.34)和剧烈活动(p = 0.33)没有显着相关。总而言之,这些数据表明维生素D的状态,BMI,日照时间,性别和哮喘/ COPD改变了补充维生素D的25(OH)D反应。相反,种族,吸烟和剧烈运动则没有。
更新日期:2020-04-30
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