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Vitrification and the demise of fresh treatment cycles in ART.
Reproductive BioMedicine Online ( IF 4 ) Pub Date : 2020-04-30 , DOI: 10.1016/j.rbmo.2020.03.017
Kamal K Ahuja 1 , Nick Macklon 1
Affiliation  

The advent of vitrification has transformed the therapeutic landscape in assisted reproductive technology. Clear evidence for this is provided by the dramatic rise in the number of frozen embryo transfer (FET) cycles being carried out annually. In this review, we examine the reasons that underlie this trend and the current evidence that points to the place FET cycles will come to inhabit in the future. Safety issues have been central to the narrative around the clinical application of vitrification and, as the evidence base grows, the risk benefit balance will become clearer for different patient groups. These will include recipients of donor eggs, as in some centres the use of cryopreserved donor eggs now exceeds that of fresh oocytes. Efficient cryopreservation techniques have also affected international transport of gametes and embryos, increasing international access. The profound changes that vitrification has created promises to fulfil a prediction made by this journal's founding Editor, Bob Edwards, that embryo and cryopreservation would solve many of the challenges presented by assisted reproductive technology.



中文翻译:

玻璃化和ART中新鲜治疗周期的消亡。

玻璃化的出现改变了辅助生殖技术的治疗前景。每年进行的冷冻胚胎移植(FET)周期数量的急剧增加提供了明确的证据。在这篇综述中,我们研究了造成这种趋势的原因,以及指出未来FET周期将在何处出现的当前证据。安全问题一直是围绕玻璃化的临床应用的叙述的中心,并且随着证据基础的增长,对于不同的患者群体,风险收益的平衡将变得更加清晰。这些将包括捐赠者卵子的接受者,因为在某些中心,冷冻保存的捐赠者卵子的使用现在已超过新鲜卵母细胞的使用。高效的冷冻保存技术也影响了配子和胚胎的国际运输,增加国际访问。玻璃化带来的深刻变化有望实现该期刊的创始编辑鲍勃·爱德华兹(Bob Edwards)所作的预测,即胚胎和冷冻保存将解决辅助生殖技术带来的许多挑战。

更新日期:2020-04-30
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