Maresin-1, a pro-resolving lipid mediator, is drawing a great deal of attention in receptor pharmacology, largely because two distinct types of receptor molecules have been reported as the targets of maresin-1. One is retinoic acid-related orphan receptor α (RORα) and the other is leucine-rich repeat domain-containing G protein-coupled receptor 6 (LGR6). RORα is a nuclear receptor and LGR6 is a plasma membrane GPCR. Identification of two different molecular targets raises the following question: What are the pro-resolving functions of each receptor in inflammation resolution, host defense, tissue homeostasis, and wound healing? In this article, I review the new targets from the point of view of pharmacology and maresin-1 resolution along with intracellular signaling molecules.

Maresin-1是促脂因子的亲分解因子，在受体药理学上引起了极大的关注，这主要是因为据报导两种不同类型的受体分子是maresin-1的靶标。一个是视黄酸相关的孤儿受体α（RORα），另一个是富含亮氨酸的重复域含G蛋白偶联受体6（LGR6）。RORα是核受体，LGR6是质膜GPCR。鉴定两个不同的分子靶标提出了以下问题：每种受体在炎症消退，宿主防御，组织稳态和伤口愈合中的促分辨功能是什么？在本文中，我将从药理学和maresin-1分辨率以及细胞内信号分子的角度审查了新的靶标。