Rats exposed prenatally to alcohol show a reduction in the spontaneous activity of dopaminergic neurons of the ventral tegmental area (VTA), as well as greater impulsive behavior and motor activity, behavioral alterations that have been related to dopaminergic dysfunction. Modafinil (MOD) is a dopamine (DA) reuptake blocker prescribed to treat sleep disorders; however, in recent years it has been used for the treatment of ADHD with positive results. Also, studies in humans and rodents show beneficial effects on learning and attention; however, studies evaluating MOD effects on impulsivity are few and show contradictory results. The purpose of this work was to evaluate the effect of a daily dose of MOD (60 mg/kg i.g.) on cognitive (or choice) impulsivity and motor activity in male preadolescent rats exposed prenatally to alcohol or sucrose (isocaloric control). MOD reduced the impulsive responses in a delay discounting task (DDT) at the same time that increased the motor activity, in both healthy and prenatal alcohol treated rats; however, MOD reduced the response latency in DDT only in prenatal alcohol treated rats. This differential effect of DA activation on impulsivity and motor activity show that the MOD dose that improves the impulse control, does not necessarily decrease motor activity, and suggests a possible differential neural mechanism underlying the expression of these behaviors. On the other hand, the changes in the response latency, only in prenatal alcohol treated groups, suggest that decision-making in animals with a dopaminergic dysfunction is more susceptible to be affected by MOD action.

产前暴露于酒精的大鼠表现出腹侧被盖区（VTA）的多巴胺能神经元的自发活动减少，以及更大的冲动行为和运动活动，这些行为改变与多巴胺能功能障碍有关。莫达非尼（MOD）是一种多巴胺（DA）再摄取阻滞剂，用于治疗睡眠障碍；然而，近年来，它已被用于治疗多动症，并取得了积极的成果。同样，对人类和啮齿动物的研究显示出对学习和注意力的有益影响。但是，评估MOD对冲动的影响的研究很少，并且显示出矛盾的结果。这项工作的目的是评估每日MOD（60 mg / kg ig ）对产前暴露于酒精或蔗糖（等热量对照）的雄性青春期前大鼠的认知（或选择）冲动和运动活动的影响。在健康和产前酒精治疗的大鼠中，MOD减少了延迟贴现任务（DDT）中的冲动反应，同时增加了运动活动；但是，MOD仅在产前酒精治疗的大鼠中降低了DDT中的反应潜伏期。DA激活对冲动和运动活动的这种不同作用表明，MOD剂量可改善冲动控制，并不一定会降低运动活动，并暗示了这些行为表达的潜在差异神经机制。另一方面，仅在产前酒精治疗组中，反应潜伏期的变化，