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Comparison of intraperitoneal ropivacaine and ropivacaine-dexmedetomidine for postoperative analgesia in cats undergoing ovariohysterectomy.
Veterinary Anaesthesia and Analgesia ( IF 1.7 ) Pub Date : 2020-02-08 , DOI: 10.1016/j.vaa.2020.01.007
Isabela Pga Nicácio 1 , Ana Beatriz F Stelle 1 , Tatiane S Bruno 1 , Gabriel M Nicácio 1 , José S Costa 1 , Renata N Cassu 1
Affiliation  

Objective

To investigate the intraperitoneal (IP) administration of ropivacaine or ropivacaine–dexmedetomidine for postoperative analgesia in cats undergoing ovariohysterectomy.

Study design

Prospective, randomized, blinded, positively controlled clinical study.

Animals

A total of 45 client-owned cats were enrolled.

Methods

The cats were administered intramuscular (IM) meperidine (6 mg kg−1) and acepromazine (0.05 mg kg−1). Anesthesia was induced with propofol and maintained with isoflurane. Meloxicam (0.2 mg kg−1) was administered subcutaneously in all cats after intubation. After the abdominal incision, the cats were administered one of three treatments (15 cats in each treatment): IP instillation of 0.9% saline solution (group Control), 0.25% ropivacaine (1 mg kg−1, group ROP) or ropivacaine and dexmedetomidine (4 μg kg−1, group ROP–DEX). During anesthesia, heart rate (HR), electrocardiography, noninvasive systolic arterial pressure (SAP) and respiratory variables were monitored. Sedation and pain were assessed preoperatively and at various time points up to 24 hours after extubation using sedation scoring, an interactive visual analog scale, the UNESP-Botucatu multidimensional composite pain scale (MCPS) and mechanical nociceptive thresholds (MNT; von Frey anesthesiometer). Rescue analgesia (morphine, 0.1 mg kg−1) IM was administered if the MCPS ≥6. Data were analyzed using the chi-square test, Tukey test, Kruskal–Wallis test and Friedman test (p < 0.05).

Results

HR was significantly lower in ROP–DEX compared with Control (p = 0.002). The pain scores, MNT, sedation scores and the postoperative rescue analgesia did not differ statistically among groups.

Conclusions and clinical relevance

As part of a multimodal pain therapy, IP ropivacaine–dexmedetomidine was associated with decreased HR intraoperatively; however, SAP remained within normal limits. Using the stated anesthetic protocol, neither IP ropivacaine nor ropivacaine–dexmedetomidine significantly improved analgesia compared with IP saline in cats undergoing ovariohysterectomy.



中文翻译:

罗哌卡因和罗哌卡因-右美托咪定用于卵巢子宫切除术猫术后镇痛的比较。

目的

研究罗哌卡因或罗哌卡因-右美托咪定在腹膜内(IP)给予卵巢子宫切除术猫的术后镇痛作用。

学习规划

前瞻性,随机,盲法,阳性对照的临床研究。

动物

总共登记了45只客户拥有的猫。

方法

给猫施用肌肉内(IM)哌啶(6 mg kg -1)和醋丙嗪(0.05 mg kg -1)。异丙酚诱导麻醉,异氟烷维持麻醉。插管后在所有猫中皮下注射美洛昔康(0.2 mg kg -1)。腹部切开后,对猫进行以下三种治疗中的一种(每次治疗15只猫):腹膜内滴注0.9%盐水溶液(对照组),0.25%罗哌卡因(1 mg kg -1,ROP组)或罗哌卡因和右美托咪定(4微克kg -1,ROP-DEX组)。麻醉期间,监测心率(HR),心电图,无创收缩压(SAP)和呼吸变量。在术前和拔管后直至24小时的各个时间点,使用镇静评分,交互式视觉模拟量表,UNESP-Botucatu多维复合疼痛量表(MCPS)和机械伤害阈值(MNT; von Frey麻醉仪)对镇静和疼痛进行评估。如果MCPS≥6,则施行急救镇痛(吗啡,0.1 mg kg -1)。使用卡方检验,Tukey检验,Kruskal–Wallis检验和Friedman检验分析数据(p <0.05)。

结果

与对照组相比,ROP-DEX的HR显着降低(p  = 0.002)。各组之间的疼痛评分,MNT,镇静评分和术后抢救镇痛无统计学差异。

结论与临床意义

作为多模式疼痛疗法的一部分,IP罗哌卡因-右美托咪定与术中HR降低相关;但是,SAP仍处于正常范围内。使用规定的麻醉方案,与接受IP生理盐水的猫进行卵巢子宫切除术相比,IP罗哌卡因和罗哌卡因-右美托咪定均不能显着改善镇痛效果。

更新日期:2020-02-08
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