Objective

To compare the neuromuscular blocking effects of cisatracurium during isoflurane versus propofol anesthesia in dogs.

Study design

Prospective, randomized study.

Animals

A total of 20 healthy, client-owned dogs (16 females, four males) weighing 12.5–22 kg and aged 1–8 years.

Methods

Dogs undergoing elective surgery were randomized in equal numbers to an isoflurane (ISO) or propofol (PPF) group. Other drugs used during anesthesia were equal between groups. Single-twitch (ST) stimulation was used to monitor neuromuscular response. After recording the baseline ST (T0), cumulative doses of cisatracurium (0.05 mg kg^–1) were administered intravenously until ST/T0 ≤5%. Effective doses 50 (ED₅₀) and 95 (ED₉₅) of cisatracurium in each group were calculated from group dose-response curves. Recovery of ST (TR) was defined as spontaneous recovery of ST to 80–120% of T0 remaining stable for 2 minutes. The ST after each dose of cisatracurium, duration 25% (time after the last dose until 25% recovery of TR), recovery index (time to recovery from 25% to 75% of TR) and duration to TR (time after the last dose until recovery of TR) were recorded.

Results

Incremental doses of cisatracurium, median (range), were 2 (1–3) in ISO and 4 (2–5) in PPF to achieve ≥95% depression of ST/T0 (p < 0.01). ED₅₀ and ED₉₅ were 20 μg kg^–1 and 117 μg kg^–1 in ISO and 128 μg kg^–1 and 167 μg kg^–1 in PPF, respectively. The duration 25%, recovery index and duration to TR, median (range), were longer in ISO [22.6 (10.3–24.3), 5.3 (3.0–7.8) and 36.1 (20.1–49.7) minutes, respectively] than in PPF [10.2 (6.8–16.5), 3.0 (2.0–3.8) and 17.7 (14.2–28.7) minutes, respectively] (p < 0.01).

Conclusions and clinical relevance

Cisatracurium-induced neuromuscular blockade was significantly enhanced and prolonged by isoflurane compared with propofol.

中文翻译：

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西沙曲库铵在异氟烷或丙泊酚麻醉期间对狗的神经肌肉阻滞作用的比较。

目的

为了比较西沙曲库铵在异氟烷与丙泊酚麻醉期间对狗的神经肌肉阻滞作用。

学习规划

前瞻性随机研究。

动物

共有20头健康的，由客户拥有的狗（16只雌性，4只雄性），重12.5-22 kg，年龄1-8岁。

方法

接受择期手术的狗被随机分为异氟烷（ISO）或丙泊酚（PPF）组。麻醉期间使用的其他药物在两组之间相同。单次抽动（ST）刺激用于监测神经肌肉反应。记录基线ST（T0）后，静脉内施用顺沙曲库铵的累积剂量（0.05 mg kg ^–1），直到ST / T0≤5％。有效剂量50（ED ₅₀）和95（ED ₉₅从组剂量反应曲线计算出每一组的顺式阿曲库铵。ST的恢复（TR）定义为ST自发恢复到80％至120％的T0并保持稳定2分钟。每次给予顺沙曲库铵后的ST，持续时间25％（从最后一剂至TR的恢复至25％的时间），恢复指数（从TR的25％至75％的恢复时间）和至TR的持续时间（最后一剂的时间）直到记录到TR的恢复为止。

结果

顺式阿曲库铵的增量剂量在ISO中为2（1-3），在PPF中为4（2-5），以达到ST / T0≥95％的降低（p <0.01）。ED ₅₀和ED ₉₅分别为20微克千克^-1和117微克千克^-1在ISO和128微克千克^-1和167微克千克^-1在PPF，分别。在ISO [22.6（10.3–24.3），5.3（3.0–7.8）和36.1（20.1–49.7）分钟]中，持续时间25％，恢复指数和达到TR的持续时间，中位数（范围）分别比PPF长[分别为10.2（6.8–16.5），3.0（2.0–3.8）和17.7（14.2–28.7）分钟]（p <0.01）。

结论与临床意义

与异丙酚相比，异氟烷显着增强了顺沙曲库铵诱导的神经肌肉阻滞。