Diffuse optical imaging (DOI) is a label-free, safe, inexpensive, and quantitative imaging modality that provides metabolic and molecular contrast in tissue using visible or near-infrared light. DOI modalities can image up to several centimeters deep in tissue, providing access to a wide range of human tissues and organ sites. DOI technologies have benefitted from several decades of academic research, which has provided a variety of platforms that prioritize imaging depth, resolution, field-of-view, spectral content, and other application-specific criteria. Until recently, however, acquisition and processing speeds have represented a stubborn barrier to further clinical exploration and implementation. Over the last several years, advances in high-speed data acquisition enabled by high-speed digital electronics, newly available sources and detectors, and innovative new scanning methods have led to major improvements in DOI rates. These advances are now being coupled with new data processing algorithms that utilize deep learning and other computationally efficient methods to provide rapid or real-time feedback in the clinic. Together, these improvements have the potential to help advance DOI technologies to the point where major impacts can be made in clinical care. Here, we review recent advances in acquisition and processing speed for several important DOI modalities.

中文翻译：

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生物医学中高速扩散光学成像的最新进展

漫射光学成像（DOI）是一种无标签，安全，便宜且定量的成像方式，可使用可见光或近红外光在组织中提供代谢和分子对比。DOI模式可以在组织深达几厘米的范围内成像，从而可以访问各种人体组织和器官部位。DOI技术得益于数十年的学术研究，该研究提供了各种平台，这些平台优先考虑成像深度，分辨率，视野，光谱内容和其他特定于应用的标准。但是，直到最近，采集和处理的速度仍是进一步临床探索和实施的顽强障碍。在过去的几年中，通过高速数字电子设备实现了高速数据采集的进步，最新可用的光源和探测器以及创新的新型扫描方法已导致DOI率得到了重大提高。这些进步现在与新的数据处理算法结合在一起，这些算法利用深度学习和其他计算有效的方法在诊所提供快速或实时反馈。总之，这些改进有可能帮助将DOI技术提升到可以在临床护理中产生重大影响的地步。在这里，我们回顾了几种重要的DOI方式在采集和处理速度方面的最新进展。这些改进有可能帮助将DOI技术提升到可以在临床护理中产生重大影响的程度。在这里，我们回顾了几种重要的DOI方式在采集和处理速度方面的最新进展。这些改进有可能帮助将DOI技术提升到可以在临床护理中产生重大影响的程度。在这里，我们回顾了几种重要的DOI方式在采集和处理速度方面的最新进展。