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Comparative Pharmacokinetics and bioavailability of marbofloxacin in geese (Anser Anser domesticus) after two sites of intramuscular administrations.
Journal of Veterinary Pharmacology and Therapeutics ( IF 1.3 ) Pub Date : 2020-03-11 , DOI: 10.1111/jvp.12853
Khaled Abo-El-Sooud 1 , Gamal A Swielim 2 , Samar M El-Gammal 2 , Meray Nabil Ramsis 2
Affiliation  

The pharmacokinetics of marbofloxacin (MAR) was compared in geese (Anser Anser domesticus ) after single intravenous (IV) and intramuscular (IM) (thigh and pectoral muscles) administrations of 5 mg/kg. Serum concentrations of MAR were determined with high‐performance liquid chromatography (HPLC) method. Serum MAR concentrations versus time were analyzed by a noncompartmental method. After IV administration, MAR showed high volume of distribution at steady state (Vdss) of 5.24 ± 1.08 L/kg. The serum body clearance (Cl) and elimination half‐life (T1/2λz) of MAR were 0.79 ± 0.07 L hr−1 kg−1 and 6.94 ± 1.12 hr, respectively. The peak of MAR serum concentrations Cmax achieved at one and 0.50 hr after thigh and pectoral IM sites of injections, respectively, were 1.20 and 0.91 μg/ml. Significant differences were found in the mean absorption time (MAT), the systemic bioavailability (F %), and elimination parameters of MAR between two sites of injections, indicating that the absorption was fairly slow and complete after thigh IM injection. The pharmacokinetics of MAR in geese diverged according to the site of IM injection following a parallel study design. We recommend the thigh muscle as IM site of injection to obtain maximum concentrations of the administered drug in geese.

中文翻译:

肌肉注射两个部位后,马波沙星在鹅中的比较药代动力学和生物利用度。

在单次静脉内(IV)和肌内(IM)(大腿和胸肌)施用5 mg / kg的鹅(Anser Anser domesticus)中比较了马波沙星(MAR)的药代动力学。MAR的血清浓度通过高效液相色谱(HPLC)方法测定。血清MAR浓度与时间的关系通过非房室方法进行分析。静脉内给药后,MAR在5.24±1.08 L / kg的稳态下(V dss)表现出较高的分布体积。MAR的血清清除率(Cl)和消除半衰期(T 1/ 2λz)分别为0.79±0.07 L hr -1  kg -1和6.94±1.12 hr。MAR血清浓度峰值C max大腿和胸部IM注射后1小时和0.50小时分别达到1.20和0.91μg/ ml。在两个注射部位之间的平均吸收时间(MAT),全身生物利用度(F%)和MAR的消除参数之间存在显着差异,表明大腿IM注射后吸收相当缓慢且完全。在平行研究设计之后,根据IM注射部位,MAR在鹅中的药代动力学有所不同。我们建议将大腿肌肉作为IM注射部位,以获取鹅中所用药物的最大浓度。
更新日期:2020-03-11
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