During the development of cosmetic formulations, in vitro and in vivo methods are essential tools used to reliably assess the skin irritation potential of a product or ingredient. Epicutaneous patch testing (single and/or multiple application protocols) has long been used as an initial in vivo method to screen for possible skin irritation properties of a substance or formulation. To confirm the mildness and dermatological and/or consumer acceptance of a product, use tests are often subsequently conducted. A study was therefore initiated to see how well patch test results correlate with use tests with respect to irritation elicited by skincare (leave‐on) products.

中文翻译：

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采用表皮贴片测试方案来评估即刻型皮肤反应。

在化妆品配方开发过程中，体外和体内方法是用于可靠评估产品或成分的皮肤刺激潜力的重要工具。表皮贴片测试（单次和/或多次应用程序）长期以来一直被用作筛选物质或制剂可能的皮肤刺激特性的初始体内方法。为了确认产品的温和性和皮肤病学和/或消费者接受度，通常随后进行使用测试。因此，启动了一项研究，以了解贴片测试结果与使用测试有关护肤（免洗）产品引起的刺激的相关性。