The circadian rhythm was set into focus by awarding the Nobel Price of Physiology/Medicine to Jeffrey Hall, Michael Rosbash and Michael Young in late 2017. Numerous publications elucidated the molecular mechanisms driving the circadian biorhythms of our body, peripheral organs and each single cell. However, there is minor knowledge on the circadian rhythm of the skin, which has its own peripheral circadian clock in contact with cosmetic formulations. The skin's epidermal clock is excessively influenced by environmental factors like UV radiation or modern lifestyle, which may induce epidermal jetlag. Here, we give an overview on the current knowledge about the epidermal circadian clock and provide a cosmetic solution to protect and preserve the biorhythm of the skin.

中文翻译：

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化妆品配方对皮肤生物钟的影响。

2017 年底，Jeffrey Hall、Michael Rosbash 和 Michael Young 获得了诺贝尔生理学/医学奖，从而使昼夜节律成为人们关注的焦点。许多出版物阐明了驱动我们身体、外周器官和每个单细胞昼夜节律的分子机制。然而，对皮肤的昼夜节律知之甚少，皮肤有自己的外围生物钟与化妆品配方接触。皮肤的表皮时钟受到紫外线辐射或现代生活方式等环境因素的过度影响，可能导致表皮时差。在这里，我们概述了有关表皮生物钟的当前知识，并提供了一种美容解决方案来保护和保持皮肤的生物节律。