Aim: To compare the outcomes of non-invasive break-up time (NI-BUT) test and the other conventional dry eye tests.

Methods: The right eyes of 170 subjects were included in the study. In order to evaluate the tear quality of the patients, NI-BUT levels were measured by the Scheimplug-Placido disk system (Sirius topography). Tear osmolarity test was performed with TearLab Osmolarity System. Topical anesthesia-assisted type I Schirmer test and topical anesthesia-assisted BUT were lastly applied to all patients in order not to affect other measurements.

Results: The mean NI-BUT value was 9.59 ± 4.37 sec, tear osmolarity was 292.93 ± 9.30 mOsm/L, Schirmer test was 15.32 ± 6.05 mm/5 min, and biomicroscopic BUT value was 8.98 ± 3.79 sec. The Schirmer test results were statistically significantly correlated with biomicroscopic BUT and NI-BUT values (p = .019, r = 0.180 and p = .030, r = 0.166; respectively). It was also found that tear osmolarity was strongly and inversely correlated with biomicroscopic BUT and topographic NI-BUT values (p < .001, r = −0.554 and p < .001, r = −0.528; respectively). There was no significant correlation between Schirmer test and tear osmolarity.

Conclusion: It is important to use a sensitive, reproducible and non-invasive method in the evaluation of tear functions. We think that the objective and noninvasive topographic NI-BUT measurements and the minimally invasive osmolarity measurements should be used more frequently in practice because they are correlated with the measurements obtained by invasive methods and should be widespread in clinics.

目的：比较无创分手时间（NI-BUT）测试和其他常规干眼测试的结果。

方法：本研究包括170名受试者的右眼。为了评估患者的泪液质量，通过Scheimplug-Placido磁盘系统（Sirius地形图）测量了NI-BUT水平。使用TearLab渗透压系统进行泪液渗透压测试。最后，将局部麻醉辅助的I型Schirmer试验和局部麻醉辅助的BUT应用于所有患者，以不影响其他测量结果。

结果：NI-BUT平均值为9.59±4.37 sec，眼泪渗透压为292.93±9.30 mOsm / L，Schirmer试验为15.32±6.05 mm / 5 min，生物显微镜BUT值为8.98±3.79 sec。Schirmer测试结果与生物显微镜BUT和NI-BUT值在统计学上显着相关（分别为p = .019，r = 0.180和p = .030，r = 0.166）。还发现泪液渗透压与生物显微镜检查的BUT和地形NI-BUT值呈显着负相关（分别为p <.001，r = -0.554和p <.001，r = -0.528 ）。Schirmer试验与泪液渗透压之间无显着相关性。

结论：使用敏感，可再现和非侵入性的方法评估泪液功能非常重要。我们认为，客观和无创性地形NI-BUT测量以及微创渗透压测量应在实践中更频繁地使用，因为它们与通过有创方法获得的测量相关，并且应在临床中广泛使用。