The purpose of this study was to investigate the association between sleep disturbances and dry eye syndrome (DES). 201 patients with DES were included in this study. Tear fluid break-up time (TBUT) and Schirmer I tests were performed. Patients with DES filled out Ocular Surface Disease Index (OSDI) questionnaire. The respondents completed the Pittsburgh Sleep Quality Index (PSQI), the Insomnia Severity Index (ISI), the Epworth Sleepiness Scale (ESS), and the STOP-Bang questionnaire. OSDI, PSQI, ISI and ESS were recorded and compared within DES severity. The study population consisted of 87.6% ( n = 176) female with age 52.33 ± 14.49 (18–80) years. The total ESS score was significantly correlated with the OSDI score ( p = 0.045), although the ESS total score was not statistically correlated with the Schirmer I test and TBUT test scores ( p = 0.239, p = 0.463). A positive correlation was identified between the total ISI score and the OSDI score ( p = 0.001). The total ISI score was negatively correlated with the Schirmer I test and TBUT test scores ( p = 0.003, p = 0.001). The total PSQI score was positively correlated with the OSDI score ( p < 0.0001), and the total PSQI score was negatively correlated with the Schirmer I test and TBUT test scores (both p < 0.0001). The total STOP-Bang score was not statistically correlated with the OSDI score, or the Schirmer I test and TBUT test scores ( p = 0.105, p = 0.399, p = 0.061, respectively). A relationship was found between DES and sleep disorders based on subjective questionnaires. Our finding suggests that the treatment of DES and sleep disorders with a multidisciplinary approach will lead to an increase in the quality of life of patients.

中文翻译：

---

OSAS风险、白天过度嗜睡、失眠严重程度和睡眠质量对干眼症的影响

本研究的目的是调查睡眠障碍与干眼症 (DES) 之间的关联。本研究包括 201 名 DES 患者。进行了泪液破裂时间 (TBUT) 和 Schirmer I 测试。DES 患者填写眼表疾病指数 (OSDI) 问卷。受访者完成了匹兹堡睡眠质量指数 (PSQI)、失眠严重程度指数 (ISI)、Epworth 嗜睡量表 (ESS) 和 STOP-Bang 问卷。OSDI、PSQI、ISI 和 ESS 被记录并在 DES 严重程度内进行比较。研究人群由 87​​.6% (n = 176) 女性组成，年龄为 52.33 ± 14.49 (18–80) 岁。ESS 总分与 OSDI 得分显着相关 (p = 0.045)，尽管 ESS 总分与 Schirmer I 测试和 TBUT 测试得分无统计学相关性 (p = 0.239, p = 0.463）。ISI 总分与 OSDI 分之间呈正相关（p = 0.001）。ISI 总分与 Schirmer I 测试和 TBUT 测试分数呈负相关（p = 0.003，p = 0.001）。PSQI 总分与 OSDI 得分呈正相关（p < 0.0001），PSQI 总分与 Schirmer I 测试和 TBUT 测试得分呈负相关（均 p < 0.0001）。总 STOP-Bang 分数与 OSDI 分数或 Schirmer I 测试和 TBUT 测试分数没有统计学相关性（分别为 p = 0.105、p = 0.399、p = 0.061）。根据主观问卷发现 DES 与睡眠障碍之间存在关系。