Culex quinquefasciatus Say is a vector for lymphatic filariasis in human populations throughout the world. Vector control, a major strategy for eradication of filariasis mainly involves the application of chemical insecticides giving rise to resistance against insecticides. In this context, a study was conducted to find out the resistance status of Cx. quinquefasciatus populations from seven densely populated sites in Siliguri sub division, West Bengal. Larval bioassay against temephos and adult bioassay against 5% malathion, 0.05% deltamethrin and 0.05% lambdacyhalothrin was performed following the standard WHO protocol. A total of 630 larvae and 360 adults were tested from one sampling site. The activity of major insecticide detoxifying enzymes i.e., carboxylesterases and monooxygenases was also assessed through biochemical assay. The seven tested populations were found to exhibit moderate to severe resistance (27.27% - 83.33% mortality) against deltamethrin, lambdacyhalothrin and temephos. However, all of the seven populations were found to be completely susceptible to malathion. This study provides new information on the current status of insecticide resistance in Cx. quinquefasciatus from this area, which may be helpful to the concerned authorities to design an effective mosquito control strategy for efficient management of vector-borne diseases.

中文翻译：

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来自印度亚喜马拉雅西孟加拉邦的 Culex quinquefasciatus 对 Temephos 和合成拟除虫菊酯的杀虫剂抗性

Culex quinquefasciatus Say 是全世界人群中淋巴丝虫病的载体。病媒控制是根除丝虫病的一项主要策略，主要涉及应用化学杀虫剂以提高对杀虫剂的抗性。在此背景下，进行了一项研究以找出 Cx 的耐药状态。来自西孟加拉邦西里古里分区七个人口稠密地点的 quinquefasciatus 种群。按照标准 WHO 方案进行针对 temephos 的幼虫生物测定和针对 5% 马拉硫磷、0.05% 溴氰菊酯和 0.05% 高效氯氟氰菊酯的成虫生物测定。从一个采样点共检测了 630 只幼虫和 360 只成虫。主要杀虫剂解毒酶，即羧酸酯酶和单加氧酶的活性也通过生化测定进行评估。发现七个测试人群对溴氰菊酯、高效氯氟氰菊酯和四甲磷表现出中度至重度耐药性（死亡率为 27.27% - 83.33%）。然而，发现所有七个种群都对马拉硫磷完全敏感。这项研究提供了关于 Cx 中杀虫剂抗性现状的新信息。quinquefasciatus，这可能有助于有关当局设计有效的蚊子控制策略，以有效管理媒介传播的疾病。