Purpose

Molecular imaging, particularly PET scanning, has become an important cancer diagnostic tool. Whole-body PET is not effective for local staging of cancer because of their declining efficiency in detecting small lesions. The preliminary results of the performance evaluation of designed dedicated breast PET scanner presented.

Methods and materials

A new scanner is based on LYSO crystals coupled with SiPM, and it consists of 14 compact modules with a transaxial FOV of 180 mm in diameter. In this study, initial GATE simulation studies were performed to predict the spatial resolution, absolute sensitivity, noise equivalent count rate (NECR) and scatter fraction (SF) of the new design. Spatial wobbling acquisitions were also implemented. Finally, the obtained projections were reconstructed using analytical and iterative algorithms.

Results

The simulation results indicate that absolute sensitivity is 1.42% which is appropriate than other commercial breast PET systems. The calculated SF and NECR in our design are 20.6% and 21.8 kcps. The initial simulation results demonstrate the potential of this design for breast cancer detection. A small wobble motion to improve spatial resolution and contrast.

Conclusion

The performance of the dedicated breast PET scanner is considered to be reasonable enough to support its use in breast cancer imaging.

中文翻译：

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开发的专用乳房 PET 扫描仪的性能评估和通过摆动提高空间分辨率：蒙特卡罗研究。

目的

分子成像，尤其是 PET 扫描，已成为重要的癌症诊断工具。全身 PET 对癌症的局部分期无效，因为它们在检测小病灶方面的效率下降。展示了设计的专用乳腺PET扫描仪性能评估的初步结果。

方法和材料

一种新型扫描仪基于 LYSO 晶体和 SiPM，它由 14 个紧凑型模块组成，具有直径 180 毫米的横轴 FOV。在这项研究中，进行了初始 GATE 模拟研究以预测新设计的空间分辨率、绝对灵敏度、噪声等效计数率 (NECR) 和散射率 (SF)。还实施了空间摆动收购。最后，使用分析和迭代算法重建获得的投影。

结果

模拟结果表明绝对灵敏度为 1.42%，比其他商业乳腺 PET 系统更合适。我们设计中计算的 SF 和 NECR 为 20.6% 和 21.8 kcps。最初的模拟结果证明了这种设计在乳腺癌检测方面的潜力。一个小的摆动运动，以提高空间分辨率和对比度。

结论

专用乳腺 PET 扫描仪的性能被认为足以支持其在乳腺癌成像中的使用。