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Intoxication by Astragalus garbancillo var. garbancillo in llamas.
The Journal of Veterinary Diagnostic Investigation ( IF 1.5 ) Pub Date : 2020-04-01 , DOI: 10.1177/1040638720914338
Raul E Marin 1, 2, 3, 4, 5, 6 , Juan F Micheloud 1, 2, 3, 4, 5, 6 , Nilda D Vignale 1, 2, 3, 4, 5, 6 , Eduardo J Gimeno 1, 2, 3, 4, 5, 6 , Donal O'Toole 1, 2, 3, 4, 5, 6 , Dale R Gardner 1, 2, 3, 4, 5, 6 , Leslie Woods 1, 2, 3, 4, 5, 6 , Francisco A Uzal 1, 2, 3, 4, 5, 6
Affiliation  

Lysosomal storage diseases are inherited and acquired disorders characterized by dysfunctional lysosomes. Intracytoplasmic accumulation of undegraded substrates leads to impaired cellular function and death. Several plant species are toxic to livestock because of the presence of indolizidine alkaloids, including swainsonine, which cause a storage disease. Swainsonine-induced nervous disease (i.e., locoism) of sheep and cattle is well recognized in several parts of the world, particularly in the western United States and in parts of Australia. Spontaneous intoxication by Astragalus garbancillo var. garbancillo was suspected in a group of 70 llamas (Lama glama) in Jujuy Province, northwestern Argentina. The animals grazed an area dominated by stands of A. garbancillo var. garbancillo. Clinical signs were staggering, ataxia, hypermetria, and progressive weight loss. The clinical course in individual animals was ~50 d. The main microscopic changes were Purkinje cell degeneration, necrosis, and loss, associated with intracytoplasmic vacuolation, meganeurite formation, and Wallerian degeneration. Specific positive labeling for ubiquitin was observed in axonal spheroids. Composite leaf and stem samples of A. garbancillo var. garbancillo analyzed by high-performance liquid chromatography contained 0.03% swainsonine. Based on the microscopic lesions, clinical history, and plant analysis, a diagnosis was made of storage disease caused by consumption of swainsonine-containing A. garbancillo var. garbancillo.

中文翻译:

黄芪garbancillo var的中毒。羊驼

溶酶体贮积病是以溶酶体功能障碍为特征的遗传性和获得性疾病。细胞质内未降解底物的积累会导致细胞功能受损和死亡。由于存在吲哚izidine生物碱(包括swainsonine),这几种植物对家畜有毒,它们会引起储存疾病。Swainsonine诱发的绵羊和牛的神经疾病(即疯牛病)在世界上许多地方都得到了公认,特别是在美国西部和澳大利亚的部分地区。黄芪garbancillo var自发中毒。涉嫌在阿根廷西北部胡胡伊省的70只美洲驼中发现了Garbancillo。这些动物在由A. garbancillo var的林分占主导的区域放牧。加尔班基洛。临床体征是惊人的,共济失调,子宫肥大,和逐步减肥。个别动物的临床病程约为50 d。微观上的主要变化是浦肯野细胞变性,坏死和丢失,与胞浆内空泡,巨突形成和沃勒变性有关。在轴突球体中观察到泛素的特异性阳性标记。A. garbancillo var的复合叶和茎样品。用高效液相色谱法分析的Garbancillo含有0.03%的swainsonine。根据微观病变,临床病史和植物分析,对由食用含swainsonine的A. garbancillo var引起的贮藏病做出诊断。加尔班基洛。与胞浆内空泡,巨突形成和沃勒变性有关。在轴突球体中观察到泛素的特异性阳性标记。A. garbancillo var的复合叶和茎样品。用高效液相色谱法分析的Garbancillo含有0.03%的swainsonine。根据微观病变,临床病史和植物分析,对由食用含swainsonine的A. garbancillo var引起的贮藏病做出诊断。加尔班基洛。与胞浆内空泡,巨突形成和沃勒变性有关。在轴突球体中观察到泛素的特异性阳性标记。A. garbancillo var的复合叶和茎样品。用高效液相色谱法分析的Garbancillo含有0.03%的swainsonine。根据微观病变,临床病史和植物分析,对由食用含swainsonine的A. garbancillo var引起的贮藏病做出诊断。加尔班基洛。并通过植物分析,诊断出因食用含swainsonine的A. garbancillo var引起的贮藏病。加尔班基洛。并通过植物分析,诊断出因食用含swainsonine的A. garbancillo var引起的贮藏病。加尔班基洛。
更新日期:2020-04-01
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