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Use of high frequency jet ventilation as a refinement for imaging macaques with respiratory disease.
Laboratory Animals ( IF 2.4 ) Pub Date : 2020-03-26 , DOI: 10.1177/0023677220913328
Sally A Sharpe 1 , Shaun Scott 2 , Irene Taylor 1 , Oliver Skinner 1 , Simon O Clark 1 , Donna Smyth 1 , Anthony McIntyre 2 , Fergus V Gleeson 2 , Mike J Dennis 1
Affiliation  

Imaging is used in human medicine to diagnose disease and monitor treatment efficacy. Computed tomography (CT) positron emission tomography (PET) and magnetic resonance (MR) are applied to animal models of infectious diseases to increase data quality, enhance their relevance to the clinical situation, and to address ethical issues through reduction of numbers and refinement of study designs. The time required for collection of MR and PET-CT scans means that normal breathing produces motion artefacts that can render images unacceptable. We report, for the first time, the use of high frequency jet ventilation (HFJV) for respiratory management during imaging of macaques. HFJV enables continuous gaseous exchange, resulting in cessation of spontaneous breathing motion thus providing a motionless field without the potential stresses induced by repeated breath-hold strategies.



中文翻译:

高频喷射通气作为对猕猴呼吸系统疾病进行成像的一种改进。

影像学在人类医学中用于诊断疾病和监测治疗效果。计算机断层扫描(CT)正电子发射断层扫描(PET)和磁共振(MR)应用于传染病的动物模型,以提高数据质量,增强其与临床状况的相关性,并通过减少数量和改进医疗质量来解决道德问题。研究设计。收集MR和PET-CT扫描所需的时间意味着正常呼吸会产生运动假象,从而使图像无法接受。我们首次报告在猕猴成像期间使用高频喷射通气(HFJV)进行呼吸管理。HFJV可实现连续的气体交换,

更新日期:2020-04-18
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