OBJECTIVES To investigate the association between insulin resistance (IR) and enlarged perivascular space (EPVS) in the basal gangliain nondiabetic healthy elderly population. METHODS A total of 235 nondiabetic healthy elderly population were recruited. A 3-level scale was used to evaluate the burden of EPVSs. The homeostasis model assessment-estimated insulin resistance index (HOMA-IR) was used for IR estimation. Correlation between IR and severity of EPVS was assessed using the regression model after adjusting demographics and cardiovascular risk factors. RESULTS The top quartile of HOMA-IR was 2.52, and 25.11% of patients showed IR. The proportion of patients with IR was higher in the moderate to severe EPVS group than in the mild group (36.51% vs 20.93%, P = .015). In multivariate logistic analysis, IR was positively correlated with the moderate to severe EPVS (adjusted odds ratio: 3.532, 95% confidence interval: 1.633-7.636, P = .001) after adjusting classical risk factors. CONCLUSIONS Insulin resistance was independently correlated with EPVS in the basal ganglia in nondiabetic healthy elderly population.

中文翻译：

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在非糖尿病健康老年人群中，胰岛素抵抗与基底神经节周围血管周围空间的增大独立相关。

目的探讨基底节非糖尿病健康老年人群中胰岛素抵抗（IR）与血管周围空间扩大（EPVS）之间的关系。方法招募了235名非糖尿病健康老年人。3级量表用于评估EPVS的负担。使用稳态模型评估评估的胰岛素抵抗指数（HOMA-IR）进行IR评估。在调整人口统计学和心血管危险因素后，使用回归模型评估IR和EPVS严重程度之间的相关性。结果HOMA-IR的最高四分位数为2.52，有25.11％的患者显示IR。中度至重度EPVS组的IR患者比例高于轻度组（36.51％vs 20.93％，P = .015）。在多元逻辑分析中，调整经典危险因素后，IR与中重​​度EPVS正相关（调整后的优势比：3.532，95％置信区间：1.633-7.636，P = .001）。结论在非糖尿病健康老年人群中，胰岛素抵抗与基底节中的EPVS独立相关。