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Clinical Features of Rickettsial Infection in Children in Tropical Australia—A Report of 15 Cases
Journal of Tropical Pediatrics ( IF 2 ) Pub Date : 2020-04-06 , DOI: 10.1093/tropej/fmaa015 Alexandra G A Stewart 1, 2 , Simon Smith 1 , Enzo Binotto 1 , Josh Hanson 1, 3
中文翻译:
热带澳大利亚儿童of病感染的临床特征-附15例报告
更新日期:2020-12-01
Journal of Tropical Pediatrics ( IF 2 ) Pub Date : 2020-04-06 , DOI: 10.1093/tropej/fmaa015 Alexandra G A Stewart 1, 2 , Simon Smith 1 , Enzo Binotto 1 , Josh Hanson 1, 3
Affiliation
Abstract
Rickettsial infections are an under-recognized cause of acute, undifferentiated fever in the tropics. In Asia, intensive care unit (ICU) admission rates as high as 21% and case-fatality rates of up to 5% have been reported. This 20-year retrospective audit of children and adults with serologically confirmed scrub typhus or spotted fever group (SFG) infection was performed at a tertiary-referral hospital in tropical Australia. There were 15 paediatric cases during the study period (11 scrub typhus, 3 SFG and 1 undifferentiated). Hypotension [5/15 (33%)], tachycardia [6/15 (40%)] and tachypnoea [6/15 (40%)] were common at presentation. Children were more likely to be hypotensive at admission than adults [5/15 (33%) vs. 5/118 (4%), p = 0.002]. However, no child died or was admitted to ICU, compared with 18/120 (15%) adults who required ICU support during the study period, one of whom died. Paediatric rickettsial infections have a relatively benign clinical course in tropical Australia with serious complications appearing far less frequently than have been reported in the Asian literature.
中文翻译:
热带澳大利亚儿童of病感染的临床特征-附15例报告
摘要
cket病感染是热带地区人们公认的急性,未发烧的病因。在亚洲,据报道重症监护病房(ICU)的入院率高达21%,病死率高达5%。在热带热带澳大利亚的一家三级转诊医院进行了这项为期20年的回顾性审核,对血清学确诊为灌木斑疹伤寒或发现发烧组(SFG)感染的儿童和成人进行了回顾。在研究期间有15例儿科病例(11例灌木斑疹伤寒,3例SFG和1例未分化)。低血压[5/15(33%)],心动过速[6/15(40%)]和心动过速[6/15(40%)]常见。儿童比成人更容易降压[5/15(33%)比5/118(4%),p = 0.002]。但是,没有儿童死亡或被ICU收治,相比之下,在研究期间需要ICU支持的18/120(15%)名成人中,有一名死亡。小儿立克次体感染在热带澳大利亚具有相对较好的临床病程,严重并发症的发生频率远低于亚洲文献报道的频率。