Syphilis has become a serious issue for human immunodeficiency virus (HIV)-infected patients worldwide in recent years; however, the studies related to HIV coinfection and syphilis reinfections in Istanbul, Turkey, are limited. Our objective was to determine the seroprevalence of syphilis among HIV-infected men in the city which has one of the highest HIV prevalence rates in Turkey. Two hundred and forty four (244) HIV-positive men were evaluated at Istanbul Medical Faculty, Department of Medical Microbiology from March to June 2018. Serum samples were screened for the presence of antibodies against Treponema pallidum using the chemiluminescent microparticle immunoassay (CMIA). Samples found to be positive were investigated with the rapid plasma reagin (RPR) test and the T. pallidum hemagglutination assay (TPHA). The patients completed a questionnaire for sociodemographic data. The mean age was found to be 41.8 years; 35.6% were men who have sex with men (MSM). The overall seroprevalence of syphilis among the patients was 19.3%. MSM had a significantly higher seroprevalence than heterosexual patients (28.7%). In Turkey, there is a high seroprevalence of syphilis in HIV-infected patients, MSM being the most affected group. Therefore, HIV-infected patients should be screened for syphilis at least annually and should be informed about sexually transmitted diseases (STDs).

近年来，梅毒已成为全球人类免疫缺陷病毒 (HIV) 感染患者的一个严重问题；然而，土耳其伊斯坦布尔与 HIV 合并感染和梅毒再感染相关的研究是有限的。我们的目标是确定该市 HIV 感染男性中梅毒的血清阳性率，该城市是土耳其 HIV 感染率最高的城市之一。2018 年 3 月至 6 月，伊斯坦布尔医学院医学微生物学系对 244 (244) 名 HIV 阳性男性进行了评估。使用化学发光微粒免疫测定法 (CMIA)筛选血清样本中是否存在针对梅毒螺旋体的抗体。使用快速血浆反应素 (RPR) 测试和梅毒螺旋体检测阳性样本血凝试验（TPHA）。患者完成了一份关于社会人口学数据的问卷。平均年龄为 41.8 岁；35.6% 是男男性行为者 (MSM)。患者中梅毒的总体血清阳性率为 19.3%。MSM 的血清阳性率明显高于异性恋患者 (28.7%)。在土耳其，HIV 感染者的梅毒血清阳性率很高，MSM 是受影响最大的群体。因此，应至少每年对 HIV 感染患者进行梅毒筛查，并了解性传播疾病 (STD)。