Abstract A novel, highly stable and green ZnCl2 nanoparticles (NPs) of modified poly(styrene-co-maleic anhydride) (SMA) was prepared by a simple procedure and was used to investigate the efficiency of the Click reaction. In this regard, SMA was modified with 3-aminopyridine to obtain the corresponding poly(styrene-co-maleimide) (SMI). ZnCl2 was immobilized onto SMI as NPs. The obtained Zn(II)-SMI nanocatalyst was characterized using various techniques including FTIR, energy-dispersive X-ray spectroscopy, scanning electron microscope image, thermogravimetric analysis and inductively coupled plasma. The catalytic activity of aforementioned NPs was successfully tested in the regioselective synthesis of 1,4-disubstituted 1,2,3-triazole. On the other hand, the design of experiment was used as a systematic method to optimize the reaction condition. Programing shows that the optimum reaction temperature and amount of catalyst are 96 °C and 0.05 g, respectively. Graphical Abstract

中文翻译：

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合成聚合物负载的 Zn(II) 作为一种新型绿色纳米催化剂，用于促进点击反应并使用实验设计优化反应条件

摘要 通过简单的方法制备了一种新型的、高度稳定的、绿色的改性聚（苯乙烯-共-马来酸酐）（SMA）ZnCl2 纳米粒子（NPs），并用于研究点击反应的效率。在这方面，SMA用3-氨基吡啶改性以获得相应的聚（苯乙烯-共-马来酰亚胺）（SMI）。ZnCl2 作为 NPs 固定在 SMI 上。使用各种技术对获得的 Zn(II)-SMI 纳米催化剂进行表征，包括 FTIR、能量色散 X 射线光谱、扫描电子显微镜图像、热重分析和电感耦合等离子体。上述NPs的催化活性在1,4-二取代1,2,3-三唑的区域选择性合成中得到了成功测试。另一方面，实验设计被用作优化反应条件的系统方法。程序表明，最佳反应温度和催化剂用量分别为96℃和0.05g。图形概要