Brimonidine is a first-line topical medication for increased intraocular pressure and glaucoma which may be used alone or in conjunction with other topical therapies. Its structural and pharmacological comparabilities to clonidine give way to the hypothesis that it may cause neuropsychiatric side effects. The majority of case reports citing brimonidine toxicity, either for topical or peripheral exposure, include pediatric age groups but especially infants. Among the latter, a dose-response phenomenon is evident. Dose-response correlates have also been shown among adults. Case series and prospective double-blind treatment studies also give evidence for the occurrence of several central nervous system adverse reactions. Topical ophthalmic brimonidine use should be followed for the occurrence of neuropsychiatric disturbances generally, and enhanced vigilance should be maintained for at-risk populations.

中文翻译：

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局部眼用溴莫尼定引起的神经精神不良事件综述。

溴莫尼定是用于增加眼内压和青光眼的一线外用药物，可单独使用或与其他外用治疗结合使用。它与可乐定的结构和药理上的可比性让位于可能引起神经精神副作用的假说。大多数病例报道溴莫尼定对局部或周边暴露均具有毒性，包括儿童年龄组，尤其是婴儿。在后者中，明显有剂量反应现象。成年人中也显示出剂量反应相关性。病例系列研究和前瞻性双盲治疗研究也为一些中枢神经系统不良反应的发生提供了证据。通常应使用局部眼用溴莫尼定治疗神经精神疾病，